PMID: 15374119Mar 1, 1997Paper

Alterations in the chaperone activity of HSP70 in aging organisms

Archives of Gerontology and Geriatrics
S Shpund, D Gershon

Abstract

The reduced capacity to respond to stress is one of the major characteristics of senescent organisms. This decline is a major cause of morbidity and eventually has lethal consequences. Heat-shock proteins (HSPs) constitute a major defense system which allows recovery from adverse modes of stress such as elevated temperatures, alcohol, toxic heavy metals (e.g., cadmium), some forms of oxidative and post-ischemic stress and other forms of environmental insults. It is, therefore, important to investigate the functional capacity of HSPs as a function of organismal age at the molecular level. We chose to test the major stress-inducible form, HSP70. This protein was purified to homogeneity from livers of young (6 months) and old (27 months) rats. Its functional capacity was examined by the ability to protect the activity of creatine kinase (CPK) and aldolase A (Ald A) treated at 56 degrees C and 51 degrees C, respectively. We first established that when HSP70 is present during the heat treatment it protected CPK by 80-90% and Ald A by 50-60%. This protection was specific and was essentially dependent upon ATP and Mg(2+). Most important, HSP70 from old rats gave only 50% protection of CPK as compared to the protein of young animals. T...Continue Reading

References

Jul 1, 1994·Pediatric Research·M J Schlesinger
Jan 1, 1993·Annual Review of Cell Biology·C Georgopoulos, W J Welch

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Citations

Jan 22, 2013·Molecular Neurobiology·Rasoul GhasemiAbolhassan Ahmadiani
Apr 27, 1999·Progress in Retinal and Eye Research·B K Derham, J J Harding
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jorge AzpuruaAndrei Seluanov
May 2, 2013·International Journal of Radiation Biology·Reshani H PereraAgata A Exner
Oct 14, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Reshani H PereraAgata A Exner
Aug 20, 2014·BioMed Research International·Khalid MahmoodJamshaid Hussain
Sep 15, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Andre VoslooDalene Vosloo
Sep 30, 2014·Trends in Pharmacological Sciences·Tony TaldoneGabriela Chiosis
Oct 3, 2001·Physiological Reviews·L H SnoeckxG J Van Der Vusse
May 26, 2017·Essays in Biochemistry·Rebecca JosefsonThomas Nyström
Mar 26, 2010·Journal of Medicinal Chemistry·Christopher G EvansJason E Gestwicki
Aug 3, 2021·Journal of Molecular Biology·Krishan GuptaDebarka Sengupta

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