Alterations in the course of acid-induced lung injury in rats after general anesthesia: volatile anesthetics versus ketamine

Anesthesia and Analgesia
N Nader-DjalalK J Johnson

Abstract

Pulmonary aspiration of gastric acid is a complication that occurs during anesthesia. The effects of the often used anesthetics on the inflammatory response after aspiration of acid are not known. We examined the effects of three different inhaled anesthetics--halothane, enflurane, and isoflurane--as well as parenteral ketamine, on the associated immediate mortality, alveolar protein leakage, and morphometric changes after intrapulmonary instillation of acidic solution in rats. Animals in deep state of anesthesia had a higher mortality after the instillation of acidic solutions than those in lighter stages (82.5% vs 31.6%). Protein leakage over 5 h was greater in the animals receiving volatile anesthetics (range 0.9-1.2) compared with those receiving ketamine (0.6 +/- 0.05). Desferoxamine did not decrease protein leakage in acid-injured animals (1.1 +/- 0.06 vs 1.02 +/- 0.08). Furthermore, volatile anesthetics resulted in an increase in the acute inflammatory response and leukocytic infiltration compared with ketamine in acid-injured lungs. We conclude that the administration of inhaled anesthetics was associated with exacerbation of an acute inflammatory response after aspiration of acidic solution. Lung injury was not increas...Continue Reading

References

Dec 1, 1979·British Journal of Anaesthesia·J F NunnD Walker
Nov 1, 1976·Anesthesia and Analgesia·P G DuncanN N Pearsall
Jul 1, 1975·Anesthesia and Analgesia·B F CullenP B Chretien
Aug 1, 1992·Journal of Applied Physiology·G GoldmanH B Hechtman
Nov 1, 1988·International Journal of Radiation Biology·M LalK D Asmus
Dec 1, 1988·Journal of Applied Physiology·B A HolmR H Notter
Jan 1, 1985·Respiration; International Review of Thoracic Diseases·W D Welch
Apr 1, 1983·The Journal of Trauma·G O TillP A Ward
Jun 1, 1982·Clinical Immunology and Immunopathology·R E LewisJ V Richey
Aug 15, 1996·Experientia·S Di MeoT De Leo

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Citations

Oct 10, 2002·Acta Anaesthesiologica Scandinavica·R S K TakalaR E Aantaa
Mar 2, 2006·Anesthesiology·Jörg ReutershanKlaus Ley
Oct 4, 2006·Current Opinion in Anaesthesiology·G C Petroz, J Lerman
Jun 5, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Cynthia A. CoxThomas H. Shaffer
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·O GiraudM Dehoux
Nov 8, 2005·American Journal of Respiratory and Critical Care Medicine·Anna M van HeeckerenPamela B Davis
Dec 19, 2009·Inhalation Toxicology·Sarah E LacherChristopher T Migliaccio
Feb 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ben T ChenG Allan Johnson
Jan 26, 2011·Critical Care Medicine·Krishnan RaghavendranPaul R Knight
Dec 17, 2003·Acta Anaesthesiologica Scandinavica·R S K TakalaR E Aantaa
Mar 12, 2011·Acta Anaesthesiologica Scandinavica·R FrithiofM Rundgren
Nov 4, 2006·Best Practice & Research. Clinical Anaesthesiology·Matthias JandaGabriele F E Nöldge-Schomburg

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