Alterations in the differentiation ability of mesenchymal stem cells in patients with nontraumatic osteonecrosis of the femoral head: comparative analysis according to the risk factor

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Jung Sub LeeKuen Tak Suh

Abstract

It has been suggested that decreased replication capacity of mesenchymal stem cells (MSCs) or decreased MSCs activity in the bone marrow is related to nontraumatic osteonecrosis (ON). However, little is known about differentiation ability of MSCs according to the risk factor of nontraumatic ON. We hypothesize that differentiation abnormalities in MSCs of the bone marrow of the proximal femurs might be related to nontraumatic ON of the femoral head. The purpose of this study was to investigate the osteogenic and adipogenic differentiation ability of MSCs in patients with nontraumatic ON of the femoral head. We examined the differentiation ability of MSCs in cultures derived from the bone marrow of the proximal femurs obtained from 10 patients with hip osteoarthritis (OA) and 37 patients with nontraumatic ON of the femoral head undergoing hip replacement surgery. We analyzed the osteogenic and adipogenic differentiation ability of MSCs according to the risk factor [alcohol-induced (15 patients), idiopathic (12 patients) and steroid-induced (10 patients)] of nontraumatic ON of the femoral head separately and compared it with patients with hip OA. The osteogenic activity was measured as the extracellular matrix calcification by ali...Continue Reading

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Citations

Jul 2, 2010·Calcified Tissue International·Ning HanZhiyong Zhang
Feb 20, 2008·International Orthopaedics·Jeong Joon YooHee Joong Kim
Apr 3, 2010·International Orthopaedics·You-Shui Gao, Chang-Qing Zhang
Feb 10, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Hui QiangLi-hong Fan
Dec 2, 2015·Experimental and Therapeutic Medicine·Rui BaiDianming Jiang
Oct 18, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Zuoqin YanZhengrong Chen
Jul 15, 2015·BMC Musculoskeletal Disorders·Yulei DongXisheng Weng
Dec 15, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xiaolin LiuChangqing Zhang
Feb 1, 2009·Proteomics. Clinical Applications·Emilio CamafeitaBenjamín Fernández-Gutiérrez
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Gang YangYun Zhu
Jun 27, 2014·The Journal of the American Academy of Orthopaedic Surgeons·Charalampos G Zalavras, Jay R Lieberman
Mar 8, 2018·International Journal of Molecular Medicine·Ding ZhouChang-Qing Zhang
Jul 26, 2011·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Asim RajpuraTimothy N Board
Oct 29, 2017·Scientific Reports·B SalmonJ A Helms
Nov 6, 2018·Journal of Hip Preservation Surgery·Athanasios V PapavasiliouCharalambos Kostantoulakis
Jun 14, 2019·Journal of Cellular Biochemistry·Shuai XiangXisheng Weng
Oct 19, 2017·Molecular Medicine Reports·Yulei DongXisheng Weng

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