PMID: 2500770Jan 1, 1989Paper

Alterations in the extracellular matrix components in human glomerular diseases

Virchows Archiv. A, Pathological Anatomy and Histopathology
A OomuraM Isemura

Abstract

We investigated the distribution of extracellular matrix components such as fibronectin, laminin, type III, IV, V, and VI collagens and heparan sulfate proteoglycan (HSPG) in normal and diseased glomeruli using the indirect immunofluorescence method. This study included 96 renal biopsies: 7 controls, 3 minimal change nephrotic syndrome (MCNS), 47 mesangial proliferative glomerulonephritis (PGN), 25 membranous nephropathy (MN) and 14 membranoproliferative glomerulonephritis (MPGN) including 3 lupus nephritis. Fibronectin was detected predominantly in the mesangium and less prominently in the glomerular basement membrane (GBM) of normal glomeruli. Laminin and type IV collagen were present in the mesangium and GBM, type III collagen in the interstitium, and type V collagen in the mesangium, interstitium and a part of GBM. Type VI collagen was observed in the mesangium, interstitium and slightly in GBM. Anti-HSPG antibody reacted with the mesangium and GBM. MCNS showed a distribution of these antigens similar to that in normal controls. The finding that staining for HSPG was not decreased in the GBM and mesangium indicated that there was no change in the core protein of HSPG. Fibronectin, laminin, type IV collagen and HSPG were inc...Continue Reading

References

Aug 23, 1976·Biochemical and Biophysical Research Communications·E ChungE J Miller
Jun 1, 1987·Kidney International·B LelongtY S Kanwar
Feb 1, 1988·Kidney International·G C GroggelW A Border
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·T NakamuraF Shimizu
Aug 1, 1986·Kidney International·D H Lovett, R B Sterzel
Jan 1, 1982·Springer Seminars in Immunopathology·P D KillenG E Striker
Mar 1, 1983·Kidney International·J I Kreisberg, M J Karnovsky
Aug 1, 1984·European Journal of Biochemistry·H von der MarkR Timpl
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J R HassellG R Martin
Apr 1, 1984·Kidney International·Y S Kanwar, M L Jakubowski
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M S WichaT Mahn
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H G HallM J Bissell
Nov 1, 1980·Journal of Clinical Pathology·A J DixonJ O McGee
Mar 1, 1981·The Journal of Cell Biology·H K KleinmanG R Martin
Feb 1, 1982·The Journal of Cell Biology·A Martinez-HernandezE J Miller
Jul 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·S FRENKJ METCOFF
Jan 1, 1959·The Journal of Experimental Medicine·R L VERNIERR A GOOD

❮ Previous
Next ❯

Citations

Jul 1, 1995·The Histochemical Journal·P LjungbergH Jalanko
Feb 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H W Schnaper
Apr 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A G NerlichE D Schleicher
Feb 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Y CaiM C Gubler
Jan 1, 1992·Progress in Growth Factor Research·N A NobleW A Border
Feb 9, 2008·Regulatory Peptides·Atsuo TaharaMasayuki Shibasaki
Jan 28, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anjali A SatoskarBrad H Rovin
Nov 30, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E FischerJ Rossert
May 1, 1996·Journal of Clinical Pathology·P N Furness
Jan 1, 1993·Mediators of Inflammation·S I YalkutV C Premyslov
Sep 20, 2011·Fibrogenesis & Tissue Repair·Wing S To, Kim S Midwood
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·L AssadV E Gould
Jun 1, 1994·Cell Adhesion and Communication·N PateyL H Noel
Feb 1, 1994·The Journal of Pathology·N Büyükbabani, D Droz
Mar 1, 1996·Kidney International·E C BergijkJ A Bruijn
Sep 1, 1992·Kidney International·S KagamiY Kuroda
Mar 13, 2003·Kidney International·Sekiko TanedaStephan Segerer
Oct 1, 1991·Kidney International·M KitamuraO Sakai
Jul 4, 2008·Kidney International·Anders A TveitaSvetlana N Zykova
Feb 1, 1994·Kidney International·J FloegeR J Johnson
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kazumasa HamanoKazuhiro Dohi
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T YasudaA B Miura
Mar 6, 1999·Molecular Genetics and Metabolism·P Mora-Garcia, K M Sakamoto
Oct 7, 2016·Pathology, Research and Practice·Laura Penna RochaRosana Rosa Miranda Corrêa
Dec 21, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Keiko NomuraTakahiko Ono

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

© 2022 Meta ULC. All rights reserved