PMID: 8945731Nov 1, 1996Paper

Alterations in the glutathione content of mitochondria following short-term forebrain ischemia in rats

Neuroscience Letters
E Zaidan, N R Sims

Abstract

Total glutathione was measured in mitochondria isolated following 30 min of ischemia and recirculation periods up to 24 h. Mitochondria prepared from the dorsolateral striatum, a region containing many neurons susceptible to short ischemic periods, were compared with those from the paramedian cortex, an ischemia-resistant region. Parallel increases in glutathione content (to approximately 150% of pre-ischemic values) were seen in both regions during the first few hours of recirculation. By 24 h of recirculation, there was a decrease below pre-ischemic values in preparations from the dorsolateral striatum but not the paramedian cortex. The early increases in mitochondrial glutathione were not associated with comparable increases in total tissue glutathione. A shorter (10 min) ischemic period also produced an early increase in mitochondrial glutathione but this was reversed more rapidly to preischemic values. The observed changes indicate post-ischemic modifications of cellular oxidative defenses in the two brain regions studied.

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Citations

Feb 19, 2002·Neurochemistry International·Neil R Sims, Michelle F Anderson
May 8, 2014·Journal of Anaesthesiology, Clinical Pharmacology·Anurag TewariFederico Bilotta
Jun 10, 1998·Biochemical and Biophysical Research Communications·S M CardosoC R Oliveira
Apr 13, 2018·Stroke; a Journal of Cerebral Circulation·Anja KahlAlexander Galkin
Sep 12, 2007·Journal of Neuroscience Research·Lucian SoaneGary Fiskum

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