Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

Antimicrobial Agents and Chemotherapy
E KanematsuY Kawada

Abstract

The gyrA and parC genes of 31 clinical isolates of Enterococcus faecalis, including fluoroquinolone-resistant isolates, were partially sequenced and analyzed for target alterations. Topoisomerase IV may be a primary target in E. faecalis, but high-level fluoroquinolone resistance was associated with simultaneous alterations in both GyrA and ParC.

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Citations

May 23, 2002·Antimicrobial Agents and Chemotherapy·Yoshikuni OnoderaKenichi Sato
May 17, 2001·Antimicrobial Agents and Chemotherapy·E A CoyleM J Rybak
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Sep 29, 2006·Journal of Medical Microbiology·Yoshihiro OyamadaJun-ichi Yamagishi
Nov 23, 2006·Antimicrobial Agents and Chemotherapy·Jose Antonio EscuderoBruno Gonzalez-Zorn
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Nov 5, 2003·International Journal of Food Microbiology·Ingo KlareWolfgang Witte

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