Alterations in the heme biosynthetic pathway from the III-V semiconductor metal, indium arsenide (InAs)

Chemico-biological Interactions
Elizabeth A ConnerB A Fowler

Abstract

The effects of indium and arsenic on the heme biosynthetic pathway have been well documented but the effects of indium arsenide (InAs), the next possible generation of the III-V semiconductors, are unknown. Male Syrian golden hamsters were given s.c. injections of sodium arsenite (As3+), indium chloride (In3+) or indium arsenide (InAs). Erythrocyte delta-aminolevulinic acid dehydratase (ALAD) activity was inhibited in all exposure groups, while hepatic ALAD activity was not significantly changed. In contrast, the activity of renal ALAD was found to be statistically decreased by As3+ at 10 days, but increased at 30 days, while In3+ and InAs inhibited this enzyme activity at all time points. In vitro studies showed that hepatic ALAD activity was more sensitive to In3+ than As3+, suggesting that the effects of InAs in vivo on this enzyme are due primarily to the In rather than the As moiety. Studies of urinary porphyrin excretion patterns in animals treated with InAs showed marked, early 2-4-fold increase in the excretion of the penta-, hexa- and heptacarboxyl porphyrin at 1-5 days which continued through day 30 of the study. In contrast, there was a slow and steady rise in the excretion of coproporphyrin I and III which reached a...Continue Reading

References

Jan 1, 1979·Archives of Oto-rhino-laryngology·S K Juhn, W D Ward
Jul 1, 1979·Toxicology and Applied Pharmacology·J S WoodsB A Fowler
Nov 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M A BowersJ S Woods
Sep 1, 1992·Toxicology and Applied Pharmacology·H YamauchiB A Fowler
Jan 1, 1987·Annals of the New York Academy of Sciences
Jan 1, 1986·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·F Eto
Oct 1, 1984·Toxicology and Applied Pharmacology·D R WebbD E Carter
May 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·C K Lim, T J Peters
Jun 15, 1984·Toxicology and Applied Pharmacology·H Yamauchi, Y Yamamura
Aug 1, 1953·The Biochemical Journal·M DIXON
Dec 1, 1955·The Biochemical Journal·K D GIBSONJ J SCOTT

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Citations

Mar 14, 2007·Bulletin of Environmental Contamination and Toxicology·Hong Wen Chen
Apr 7, 2007·Bulletin of Environmental Contamination and Toxicology·H-W Chen
Jul 28, 2004·Toxicology and Applied Pharmacology·Akiyo Tanaka
Oct 18, 2000·Toxicology Letters·V L Pimentel VieiraP C do Nascimento
Apr 20, 2011·Clinical and Experimental Pharmacology & Physiology·Swaran J S FloraPramod K Kushwah
Feb 18, 2011·Journal of Occupational Health·Ryo TakagiHiroyuki Yanagisawa
Jul 21, 2011·Toxicology Letters·Perrine HoetDominique Lison
Jul 22, 2014·Environmental Toxicology·Kuo-Hsin LeePing-Chi Hsu
Jun 13, 2008·Reproductive Toxicology·Mikio NakajimaMakoto Usami
Jun 22, 2005·Toxicology and Applied Pharmacology·Bruce A FowlerHiroshi Yamauchi
May 16, 2006·International Journal of Environmental Research and Public Health·Laila N IslamAzizul I Kazi
Mar 31, 2005·Journal of Environmental Monitoring : JEM·Marijn Van HulleRita Cornelis
Oct 4, 2016·Current Environmental Health Reports·Sarah Jane O White, James P Shine
Oct 20, 1999·Archives of Biochemistry and Biophysics·J M JacobsJ F Sinclair
Mar 21, 2008·Toxicology and Applied Pharmacology·Bruce A FowlerHiroshi Yamauchi

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