PMID: 6979670Jan 1, 1982Paper

Alterations in the immunogenic properties of sheep erythrocytes by sonic disruption

Microbiology and Immunology
F NagaseN Kato

Abstract

A solubilized sheep red blood cell (SRBC) antigen (supernatant fraction obtained by centrifuging 10(7)-2 x 108 sonicated SRBC at 6 x 10(4) g for 30 min [Sup-SRBC]), whose ability to inhibit anti-SRBC plaque formation was 70% of that of the original sonicated SRBC, was unable to elicit a detectable antibody response in either unprimed or SRBC-primed mice. However, Sup-SRBC as well as intact SRBC antigens generated memory for the secondary response, which was transferable to irradiated syngeneic recipients by injection of immune spleen cells. The memory generated by Sup-SRBC involved helper memory for anti-trinitrophenyl group (TNP) response to challenge with TNP-conjugated SRBC. Increase in the helper T cell memory in the spleens of Sup-SRBC-primed mice was also demonstrated by an in vitro culture experiment and by an adoptive cell transfer experiment. In contrast, no detectable B cell memory was generated by Sup-SRBC. Repeated stimulation with Sup-SRBC never induced significant antibody response but reduced the level of memory. A single injection of a low dose (10(6)) of SRBC also failed to induce a definite primary antibody response generating memory for the secondary response. However, repeated stimulation with this dose of S...Continue Reading

References

Dec 1, 1972·The Journal of Experimental Medicine·T H AndersonR Auerbach
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J Kettman, R W Dutton
Sep 1, 1972·The Journal of Experimental Medicine·G Dennert, D F Tucker
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D E Mosier, L W Coppleson

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