Alterations in the mechanical behavior of the human lumbar nucleus pulposus with degeneration and aging

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
James C IatridisV C Mow

Abstract

This study tested the hypothesis that changes in the morphology and composition of the nucleus pulposus with age and degeneration have associated changes in its mechanical properties. A torsional shear experiment was used to determine viscoelastic shear properties of cylindrical samples of human nucleus pulposus with large ranges of grades of morphological degeneration (normal to severely degenerated) and ages (range: 16-88 years; average: 57 +/- 21.5 years). Viscoelastic shear properties were determined from stress-relaxation and dynamic sinusoidal tests. A linear viscoelastic law with a variable-amplitude relaxation spectrum was used to model experimental behaviors of nucleus pulposus specimens. A statistically significant increase in the instantaneous and dynamic shear moduli was found with increasing age and grade of degeneration; the values for moduli ranged from 5.0 to 60 kPa. A significant decrease in tan delta was also detected; the values ranged from 0.43 to 0.33, indicating a decreased capacity for the nucleus pulposus to dissipate energy. The dynamic modulus and tan delta were also significantly affected by frequency. It was generally concluded that the nucleus pulposus undergoes a transition from "fluid-like" behavi...Continue Reading

References

Jan 1, 1987·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R H PearceM E Adams
Jan 1, 1986·Journal of Biomechanics·A Shirazi-AdlS C Shrivastava
Dec 10, 1997·Journal of Biomechanics·J C IatridisV C Mow
Jan 1, 1960·Acta Orthopaedica Scandinavica. Supplementum·A NACHEMSON

❮ Previous
Next ❯

Citations

Sep 19, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Stephen J Ferguson, Thomas Steffen
Feb 17, 2006·Annals of Biomedical Engineering·Wade JohannessenDawn M Elliott
Mar 23, 2010·Annals of Biomedical Engineering·Ian A StokesJeffrey P Laible
Dec 10, 1997·Journal of Biomechanics·J C IatridisV C Mow
Jan 1, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jason P NorcrossLaurence E Dahners
Feb 22, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Alicia R JacksonWei Yong Gu
Oct 23, 2012·Journal of Biomechanical Engineering·Ugur M AyturkChristian M Puttlitz
Feb 4, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Tina M NagelDavid J Nuckley
Nov 20, 2013·The Spine Journal : Official Journal of the North American Spine Society·Kevin K ChengJeffrey C Lotz
Feb 2, 2013·The Spine Journal : Official Journal of the North American Spine Society·James C IatridisMichelle S Gupta
Sep 29, 2011·The Orthopedic Clinics of North America·Nozomu Inoue, Alejandro A Espinoza Orías
Jan 17, 2012·Mechanics of Materials : an International Journal·Sounok SenDawn M Elliott
Jan 9, 2016·Magnetic Resonance Imaging·Ephraim I Ben-AbrahamRichard L Ehman
Sep 8, 2010·Journal of Biomechanics·Aaron J FieldsTony M Keaveny
Feb 12, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Shujie Tang, Brandon J Rebholz
Oct 16, 2009·Journal of Biomechanics·Adam H Hsieh, Julianne D Twomey
Dec 20, 2015·Journal of Biomechanics·Pieter-Paul A VergroesenTheodoor H Smit
Jan 6, 2009·Materials Science & Engineering. R, Reports : a Review Journal·Dominic ChowAshutosh Chilkoti
Jun 24, 2008·Journal of Biomechanics·Marco CannellaMichele Marcolongo
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth Sornay-RenduUNKNOWN OFELY Study
Nov 2, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kaspar-Josche StreitbergerIngolf Sack
Apr 12, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·David J NuckleyRandal P Ching
Jan 19, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Senthil K EswaranTony M Keaveny

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.