Alterations in the mucosa-associated fungal microbiota in patients with ulcerative colitis

Oncotarget
Xinyun QiuHongjie Zhang

Abstract

Fungi colonize the human gut and might play a key role in the pathogenesis of ulcerative colitis (UC). However, studies on the fungal composition in the gut (especially adhering to the intestinal mucosa) of UC patients is limited. The number of fungi decreased significantly in inflamed mucosa compared with that in HS mucosa. Fifteen major genera were examined, among which Wickerhamomyces, unidentified genus of Saccharomycetales, Aspergillus, Sterigmatomyces, and Candida showed increasing trends, whereas Exophiala, Alternaria, Emericella, Epicoccum, Acremonium, Trametes, and Penicillium showed decreasing trends in UC patients compared to the HS. The pro-inflammatory cytokines (IL-Iβ, TNF-α, INF-γ, IL-6, IL-17A, and IL-23) were up-regulated in the UC group. The genera Wickerhamomyces, Nigrospora, and Penicillium were positively correlated, while Sporobolomyces and Trametes were negatively correlated with the expression of several colonic pro-inflammatory cytokines and the Baron and/or Mayo score. Our study confirms the alteration of the colonic fungal microbiota in the UC patients, which might be associated with mucosal inflammation and pathogenesis of UC. Further studies need to identify the roles of different intestinal fungi i...Continue Reading

References

Dec 17, 2002·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Francesc CasellasJuan-Ramon Malagelada
Jun 17, 2005·The New England Journal of Medicine·Brian G FeaganMargaret K Vandervoort
Jul 18, 2006·Journal of Immunological Methods·Lisa M GrahamGordon D Brown
Dec 18, 2012·Applied and Environmental Microbiology·Suzanne F DagherJosé M Bruno-Bárcena
Jun 5, 2013·Microbial Ecology·Na WuBaoli Zhu
Nov 28, 2013·Journal of Clinical Gastroenterology·Qiurong LiJieshou Li
Feb 25, 2014·Gastroenterology·Aleksandar D KosticDirk Gevers
Apr 23, 2014·Nature Reviews. Immunology·Markus F Neurath
May 24, 2014·Nature Reviews. Immunology·David M Underhill, Iliyan D Iliev
Jan 1, 2013·Journal of Surgical Case Reports·Jennifer H FieberWalter E Longo
Sep 14, 2014·Gut·Siew C NgUNKNOWN Asia-Pacific Crohn's and Colitis Epidemiology Study ACCESS Group
Nov 26, 2014·Seminars in Immunopathology·Anthony PlatoGordon D Brown
Jan 7, 2015·Pharmacology & Therapeutics·Giovanni CammarotaDiego Currò
Nov 18, 2015·Journal of Crohn's & Colitis·Giuseppina LiguoriHarry Sokol
Feb 5, 2016·Gut·Harry SokolLaurent Beaugerie
Feb 24, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·David Marti AguadoMarta Maia Bosca Watts

❮ Previous
Next ❯

Citations

Sep 27, 2018·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ghee Chuan LaiNorman Pavelka
Nov 22, 2019·Inflammatory Bowel Diseases·Xu JunLiu Yulan
Jul 22, 2018·Clinical Journal of Gastroenterology·Jun MiyoshiJoseph Francis Pierre
Feb 11, 2020·Journal of Digestive Diseases·Xiao Yan GuoJian Yu Hao
Jan 10, 2021·Mycoses·Alireza Beheshti-MaalMohammad Reza Zali
Dec 10, 2020·Journal of Clinical Biochemistry and Nutrition·Young-Min HanKi Baik Hahm
Jul 28, 2020·Life Sciences·Roberto de Paula do NascimentoMario Roberto Maróstica Junior
Apr 4, 2021·International Journal of Molecular Sciences·Laila Aldars-GarcíaJavier P Gisbert
Apr 20, 2021·Therapeutic Advances in Gastroenterology·Jordan E AxelradShailja C Shah
May 10, 2021·Gut Pathogens·Elaheh MahmoudiNiusha Sharifinejad
Jul 30, 2021·Comprehensive Reviews in Food Science and Food Safety·Georg AichingerDoris Marko
Aug 17, 2021·Scandinavian Journal of Gastroenterology·Sui WangYan-Bo Yu

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
biopsies
biopsy

Software Mentioned

PLS
Simca
Statistical Package for Social Sciences
DA
TMEV Multiple Experiment Viewer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.