Alterations in the muscarinic M1 and M3 receptor gene expression in the brain stem during pancreatic regeneration and insulin secretion in weanling rats

Life Sciences
T R RenukaC S Paulose

Abstract

Muscarinic M1 and M3 receptor changes in the brain stem during pancreatic regeneration were investigated. Brain stem acetylcholine esterase activity decreased at the time of regeneration. Sympathetic activity also decreased as indicated by the norepinephrine (NE) and epinephrine (EPI) content of adrenals and also in the plasma. Muscarinic M1 and M3 receptors showed reciprocal changes in the brain stem during regeneration. Muscarinic M1 receptor number decreased at time of regeneration without any change in the affinity. High affinity M3 receptors showed an increase in the number. The affinity did not show any change. The number of low affinity receptors decreased with decreased Kd at 72 hours after partial pancreatectomy. The Kd reversed to control value with a reversal of the number of receptors to near control value. Gene expression studies also showed a similar change in the mRNA level of M1 and M3 receptors. These alterations in the muscarinic receptors regulate sympathetic activity and maintain glucose level during pancreatic regeneration. Central muscarinic M1 and M3 receptor subtypes functional balance is suggested to regulate sympathetic and parasympathetic activity, which in turn control the islet cell proliferation an...Continue Reading

References

Aug 1, 1985·Acta Endocrinologica·A IguchiN Sakamoto
Feb 1, 1988·Diabetes·J S BrockenbroughS Bonner-Weir
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Citations

Mar 8, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·T R AnjuC S Paulose
Jun 27, 2008·Pancreas·Sankara Balarama KaimalChiramadathikudiyil Skaria Paulose
Sep 10, 2013·Endocrinology and Metabolism Clinics of North America·Chao Deng
Oct 11, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Katrina Weston-GreenChao Deng
Nov 9, 2010·Behavioural Brain Research·Katrina Weston-GreenChao Deng
Jul 14, 2005·Molecular and Cellular Biochemistry·Valiya Veettil MohananCheramadathikudyil S Paulose

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