Alterations in the muscle-to-capillary interface in patients with different degrees of chronic obstructive pulmonary disease.

Respiratory Research
Gabriella EliasonF Kadi

Abstract

It is hypothesized that decreased capillarization of limb skeletal muscle is implicated in the decreased exercise tolerance in COPD patients. We have recently demonstrated decreased number of capillaries per muscle fibre (CAF) but no changes in CAF in relation to fibre area (CAFA), which is based on the diffusion distance between the capillary and muscle fibre. The aim of the current study is to investigate the muscle-to-capillary interface which is an important factor involved in oxygen supply to the muscle that has previously been suggested to be a more sensitive marker for changes in the capillary bed compared to CAF and CAFA. 23 COPD patients and 12 age-matched healthy subjects participated in the study. Muscle-to-capillary interface was assessed in muscle biopsies from the tibialis anterior muscle using the following parameters:1) The capillary-to-fibre ratio (C:Fi) which is defined as the sum of the fractional contributions of all capillary contacts around the fibre2) The ratio between C:Fi and the fibre perimeter (CFPE-index)3) The ratio between length of capillary and fibre perimeter (LC/PF) which is also referred to as the index of tortuosity.Exercise capacity was determined using the 6-min walking test. A positive cor...Continue Reading

References

Oct 1, 1992·International Journal of Sports Medicine·H Hoppeler, D Desplanches
Jan 1, 1992·Medicine and Science in Sports and Exercise·C R HonigT E Gayeski
Jan 1, 1993·Annual Review of Physiology·O Mathieu-Costello
Feb 1, 1997·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·R T Hepple
Apr 29, 1998·Acta Neuropathologica·F KadiL E Thornell
Dec 19, 1998·Journal of Cardiopulmonary Rehabilitation·J JobinC Simard
Jun 10, 2000·Chest·E F Wouters
Mar 10, 2001·Experimental Cell Research·K Kondo, W G Kaelin
Jun 21, 2001·Respiration; International Review of Thoracic Diseases·A Aliverti, P T Macklem
Oct 20, 2001·Journal of Applied Physiology·R T Hepple, O Mathieu-Costello
Oct 30, 2001·High Altitude Medicine & Biology·O Mathieu-Costello
Nov 1, 2001·Respiratory Research·M J Mador, E Bozkanat
Oct 4, 2002·Muscle & Nerve·Michelle M PorterJan Lexell
Jun 18, 2003·Muscle & Nerve·Nadia CharifiChristian Denis
Sep 2, 2003·Journal of Applied Physiology·Timothy P GavinRobert C Hickner
Nov 19, 2003·The European Respiratory Journal. Supplement·R T Jagoe, M P K J Engelen
Jan 25, 2005·American Journal of Respiratory and Critical Care Medicine·Fabio PittaRik Gosselink
Oct 13, 2005·Respiratory Medicine·Marc DecramerStefano Marinari
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease
Aug 30, 2008·American Journal of Respiratory and Critical Care Medicine·Martin PicardYan Burelle
Nov 5, 2008·Scandinavian Journal of Medicine & Science in Sports·G EliasonK Piehl-Aulin

❮ Previous
Next ❯

Citations

Jan 21, 2014·Respiratory Research·Philippe GagnonFrançois Maltais
May 3, 2014·American Journal of Respiratory and Critical Care Medicine·François MaltaisUNKNOWN ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD
Oct 28, 2015·Annals of Neurology·Eilidh SomersSimon H Parson
Jul 7, 2015·Clinical Physiology and Functional Imaging·Ana Alice Soares Dos SantosLuiz Carlos Marques Vanderlei
Jan 18, 2011·British Journal of Hospital Medicine·Lea Breunung, Mike Roberts
Nov 28, 2014·Journal of Applied Physiology·C C de TheijeS E Köhler
Mar 16, 2017·American Journal of Physiology. Endocrinology and Metabolism·Gwenael LayecRussell S Richardson
Nov 4, 2015·Physiology·Claire LatrocheBénédicte Chazaud
Dec 15, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Bruce A CorlissShayn M Peirce
Apr 19, 2021·Respiratory Physiology & Neurobiology·Murillo FrazãoMaria do Socorro Brasileiro-Santos
Jul 8, 2021·Journal of Translational Medicine·Knut Sindre MølmenStian Ellefsen

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

Statistix

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

CFTR Mutant Structural Therapy

Over 1700 different mutations in the CFTR genes have been shown to cause cystic fibrosis. Here is the latest research on structural therapy for CFTR mutants.