Alterations in the non-neuronal acetylcholine synthesis and release machinery in esophageal epithelium.

Life Sciences
Amanda S Wolf-JohnstonLori A Birder

Abstract

A non-neuronal cholinergic system has been described in epithelial cells including that of the urinary bladder (urothelium) and the upper gastrointestinal tract (esophagus). Epithelial dysfunction has been implicated in the pathophysiology of persistent pain conditions such as painful bladder syndrome as well as functional heartburn. For example, alterations in the ability to synthesize and release acetylcholine may contribute to changes in epithelial sensory and barrier function associated with a number of functional genitourinary and intestinal disorders. We examined using immunoblot, acetylcholine (ACh)-synthesis and release components in cat esophageal mucosa and whether elements of these components are altered in a naturally occurring model of chronic idiopathic cystitis termed feline interstitial cystitis (FIC). We identified proteins involved in ACh synthesis and release (high affinity choline transporter, CHT1; ACh synthesizing enzyme choline acetyltransferase ChAT and carnitine acetyltransferase CarAT; vesicular ACh transporter VAChT and the organic cation transporter isoforms 1-3 or OCT-1-3) in cat esophageal mucosa. Significant alterations in CHT, ChAT, VAChT and OCT-1 were detected in the esophageal mucosa from FIC ...Continue Reading

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Citations

Jun 6, 2014·BioMed Research International·Susan K KeayToby C Chai
Oct 31, 2015·Annual Review of Pharmacology and Toxicology·Hiroshi OmoteYoshinori Moriyama
May 6, 2014·Journal of Feline Medicine and Surgery·C A Tony BuffingtonDennis J Chew
Jun 16, 2017·Purinergic Signalling·Yoshinori MoriyamaMasatoshi Nomura
Feb 13, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Giselle BravoDonna J Sellers
Aug 1, 2020·Frontiers in Cell and Developmental Biology·Jun PanJian Huang
Jul 3, 2020·European Journal of Pharmacology·Andrzej WróbelPiotr Radziszewski
Jun 3, 2021·International Journal of Molecular Sciences·Andrzej WróbelPiotr Radziszewski

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