PMID: 9441715Jan 27, 1998Paper

Alterations in the reproductive patterns of female mice exposed to xenobiotics

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
J B BishopW M Generoso

Abstract

Chemicals, by virtue of their varied interactions with biological molecules, are expected to differ in the way they may alter female reproduction. Reproductive toxicity may reflect effects either on the female germ cells or on various maternal processes such as ovulation, implantation, pregnancy, and parturition. In either case, the ultimate manifestation of chemical toxicity on female reproduction is a decrease in the number of normal young born. Very little information is available on the effects of chemicals that are nonhormonal in nature on the long-term ability of treated females to produce offspring. This report presents the results of long-term female total reproductive capacity (TRC) tests on 29 chemicals, including pharmaceuticals, pesticides, and alkylating and industrial agents. For each chemical, the minimum test involved an evaluation of the maximum tolerated dose administered as a single intraperitoneal injection. Females were single-pair mated with an untreated male for most of the female's reproductive life span (a minimum of 347 days posttreatment) and scored for the number of live births produced during this period. Confirmatory dominant lethal experiments or histological examinations for numbers of small foll...Continue Reading

Citations

Mar 26, 2011·PloS One·Loro L KujjoGloria I Perez
Sep 9, 2004·Mutation Research·Awadhesh N Jha
Jul 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Spiros MiyakisSteven A Krilis
Feb 25, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jeanne MansonPeter Working
Oct 21, 2006·Environmental Research·Ilse-Dore AdlerFrancesca Pacchierotti
May 15, 2004·Science·Jonathan M SametHeinrich V Malling

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