Alterations in the RTK/Ras/PI3K/AKT pathway serve as potential biomarkers for immunotherapy outcome of diffuse gliomas.

Aging
Song HanChang-Xiang Yan

Abstract

Diffuse gliomas are the most common malignant brain tumors, and immune checkpoint inhibitors have limited therapeutic effects against this cancer. Three oncogenic pathways are altered in diffuse gliomas: the RTK/Ras/PI3K/AKT signaling, TP53, and RB pathways. Although these pathways may affect the tumor immune microenvironment, their association with immunotherapy biomarkers remains unclear. We used copy number variation and mutation data to stratify patients with specific oncogenic signaling alterations, and evaluated their correlation with predictive immunotherapy biomarkers, including tumor mutation burden (TMB), immune cytolytic activity (CYT), tumor purity, and tumor-infiltrating CD8+ T cells. Immune checkpoint expression and interferon-γ signaling activity were also compared in these samples. We identified differentially expressed genes in three distinct oncogenic pathways. Gene ontology analysis of these genes revealed the involvement of RTK/Ras/PI3K/AKT-associated genes in immune and inflammatory responses. Moreover, significantly elevated TMB, CYT, and numbers of CD8+ T cells and decreased tumor purity were correlated with altered RTK/Ras/PI3K/AKT signaling. Single cell sequencing also confirmed that this tumor subgroup...Continue Reading

References

Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert L CampDavid L Rimm
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Apr 18, 2012·Genes & Development·Gavin P DunnWilliam C Hahn
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Oct 12, 2013·Nature Communications·Kosuke YoshiharaRoel G W Verhaak
Oct 15, 2013·Cell·Cameron W BrennanUNKNOWN TCGA Research Network
Feb 21, 2014·The New England Journal of Medicine·Olivier L ChinotTimothy Cloughesy
May 16, 2015·Cancer Research·Michele W L TengMark J Smyth
Jan 29, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chan-Young OckDae Seog Heo
Mar 12, 2016·Oncotarget·Xiaoman LiLiang Wang
Apr 17, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Priti S HegdeStefan Evers
Jan 1, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhong-Yi DongYi-Long Wu
Mar 16, 2017·Cancer Cell·Daniela F Quail, Johanna A Joyce
Apr 20, 2017·Genome Medicine·Zachary R ChalmersGarrett M Frampton
May 14, 2017·Journal of Neuro-oncology·Marc C Chamberlain, Bryan T Kim
Jul 30, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chuanbao ZhangAnhua Wu
Jun 27, 2019·International Journal of Cancer. Journal International Du Cancer·Sang-Soo KimEsther H Chang
Aug 21, 2019·Frontiers in Immunology·Zhi-Liang WangTao Jiang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

GSEA
cBioPortal
edgeR
DAVID
GSVA
Java
R
SingleCellPortal
ssGSEA
tile

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Related Papers

Cancer Management and Research
Mengting TongHongliang Zhang
Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
Elisabeth Pérez-RuizJavier De Las Rivas
International Journal of Molecular Sciences
Sara BravacciniPaola Ulivi
© 2021 Meta ULC. All rights reserved