Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis.

Arthritis Research & Therapy
Sindhu T MohantyIlaria Bellantuono

Abstract

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease. Abnormalities in haemopoietic stem cells' (HSC) survival, proliferation and aging have been described in patients affected by RA and ascribed to abnormal support by the BM microenvironment. Mesenchymal stem cells (MSC) and their progeny constitute important components of the BM niche. In this study we test the hypothesis that the onset of inflammatory arthritis is associated with altered self-renewal and differentiation of bone marrow MSC, which alters the composition of the BM microenvironment. We have used Balb/C Interleukin-1 receptor antagonist knock-out mice, which spontaneously develop RA-like disease in 100% of mice by 20 weeks of age to determine the number of mesenchymal progenitors and their differentiated progeny before, at the start and with progression of the disease. We showed a decrease in the number of mesenchymal progenitors with adipogenic potential and decreased bone marrow adipogenesis before disease onset. This is associated with a decrease in osteoclastogenesis. Moreover, at ...Continue Reading

References

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Citations

Mar 2, 2011·Current Osteoporosis Reports·Monique BethelMelissa A Kacena
Nov 3, 2011·Bone Marrow Research·Tian Li, Yaojiong Wu
Sep 2, 2010·Arthritis Research & Therapy·Christian Jorgensen
Nov 29, 2015·Experimental Hematology·Ana Cordeiro Gomes, Maria Salomé Gomes
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Jul 24, 2012·Experimental Gerontology·Günter Lepperdinger
Feb 12, 2015·Journal of Neuroimmunology·Jian KangXiaojian Zhang
Jun 6, 2012·Stem Cells International·Sally A Boxall, Elena Jones
Mar 22, 2018·Inflammation and Regeneration·Kaoru YamagataYoshiya Tanaka
Apr 3, 2016·Journal of Leukocyte Biology·Dessi LoukovDawn M E Bowdish

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Methods Mentioned

BETA
FCS
light microscopy
X-ray
transgenic

Software Mentioned

Skyscan Recon
Skyscan CT
Osteomeasure

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