Alterations in the surface properties of lung surfactant in the torpid marsupial Sminthopsis crassicaudata

Journal of Applied Physiology
O V LopatkoD Palmer

Abstract

Torpor changes the composition of pulmonary surfactant (PS) in the dunnart Sminthopsis crassicaudata [C. Langman, S. Orgeig, and C. B. Daniels. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol, 40): R437-R445, 1996]. Here we investigated the surface activity of PS in vitro. Five micrograms of phospholipid per centimeter squared surface area of whole lavage (from mice or from warm-active, 4-, or 8-h torpid dunnarts) were applied dropwise onto the sub-phase of a Wilhelmy-Langmuir balance at 20 degrees C and stabilized for 20 min. After 4 h of torpor, the adsorption rate increased, and equilibrium surface tension (STeq), minimal surface tension (STmin), and the %area compression required to achieve STmin decreased, compared with the warm-active group. After 8 h of torpor, STmin decreased [from 5.2 +/- 0.3 to 4.1 +/- 0.3 (SE) mN/m]; %area compression required to achieve STmin decreased (from 43.4 +/- 1.0 to 27.4 +/- 0.8); the rate of adsorption decreased; and STeq increased (from 26.3 +/- 0.5 to 38.6 +/- 1.3 mN/m). ST-area isotherms of warm-active dunnarts and mice at 20 degrees C had a shoulder on compression and a plateau on expansion. These disappeared on the isotherms of torpid dunnarts. Samples of whole lavage (from w...Continue Reading

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Citations

Jul 23, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carol J LangChristopher B Daniels
Mar 30, 2002·Biochimica Et Biophysica Acta·Jonathan R CoddSandra Orgeig
May 23, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·C B Daniels, S Orgeig
Mar 20, 2001·Biophysical Chemistry·M Gugliotti, M J Politi
Nov 14, 1998·Biochimica Et Biophysica Acta·R VeldhuizenF Possmayer
Oct 11, 2003·Biochemical and Biophysical Research Communications·Carol J OrmondChristopher B Daniels
Feb 16, 2006·Respiratory Physiology & Neurobiology·Natalie J MillerSandra Orgeig

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