Alterations in the T-cell receptor variable beta gene-restricted profile of CD8+ T lymphocytes in the peripheral circulation of patients with squamous cell carcinoma of the head and neck

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Andreas E AlbersAlbert B De Leo

Abstract

Apoptosis of activated CD8(+) T cells is often seen in tumor-infiltrating lymphocytes and circulating peripheral blood mononuclear cells (PBMC) in patients with squamous cell carcinoma of the head and neck (SCCHN). We investigated whether T-cell receptor (TCR) variable beta chain (Vbeta)-restricted T cells were more sensitive to apoptosis than non-TCR Vbeta-restricted T cells. Flow cytometry analysis with anti-TCR Vbeta antibodies was used to define expansions and contractions of Vbeta-restricted T cells in patients with SCCHN relative to normal donors. This staining was combined with Annexin V binding to indicate early T-cell apoptosis. The TCR Vbeta profiles of CD3(+) T cells in tumor-infiltrating lymphocytes and PBMCs of patients with SCCHN were altered relative to controls, with one to five expansions and numerous contractions of TCR Vbeta-restricted T cells detected. These types of alterations were significantly greater in CD8(+) than CD4(+) T cells. Enhanced Annexin V binding to CD8(+) T cells was evident in PBMCs obtained from all patients, with 3 of 13 showing preferential targeting for apoptosis of TCR Vbeta-restricted T cells. TCR Vbeta profiles of CD8(+) T cells were altered in patients with SCCHN relative to normal ...Continue Reading

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Citations

Feb 1, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Malgorzata CzystowskaTheresa L Whiteside
Apr 14, 2010·Journal of Translational Medicine·Sebastian OchsenreitherDirk Nagorsen
Jan 15, 2011·Clinical & Developmental Immunology·A E AlbersA M Kaufmann
Mar 17, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shigeo KoidoHisao Tajiri
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Dec 21, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christina M CoughlinRobert H Vonderheide

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