PMID: 1193419Nov 1, 1975Paper

Alterations in tissue ferritins in iron storage disorders

Gut
L W PowellJ W Halliday

Abstract

Purified tissue ferritins isolated from Bantu subjects with gross haemosiderosis, from a patient with idiopathic haemochromatosis (HC) treated by phlebotomy, and from rats with experimental iron overload were studied in order to determine the significance of the abnormality previously demonstrated in tissue isoferritins in patients with IHC. The isoferrin profile of the tissues from the Bantu subjects and the iron-loaded rats showed a similar abnormality to that previously found in patients with untreated IHC--that is, an abnormally uniform distribution of iron-containing isoferritins with an increase in the more basic isoferritins and an apparent absence of the more acidic ones. In contrast, tissues from the patient with treated IHC, who was iron depleted at the time of death, showed the normal organ-specific isoferritin distribution. These findings strongly suggest that the abnormal distribution of tissue isoferritins in IHC is an acquired phenomenon and unlikely to be related to an underlying genetic defect in ferritin or iron metabolism.

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Citations

Jan 1, 1980·Progress in Biophysics and Molecular Biology·G A CleggA Treffry
Aug 20, 1983·Lancet·D ShuttleworthR Slade
Sep 1, 2009·Journal of Toxicologic Pathology·Kaori MiyataSatoshi Uwagawa
Dec 11, 1980·Biochimica Et Biophysica Acta·A Treffry, P M Harrison
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·G D McLarenR W Kellermeyer
Jan 1, 1978·CRC Critical Reviews in Clinical Laboratory Sciences·C P Alfrey
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lawrie W Powell
Jan 1, 1980·Disease-a-month : DM·M L BassettL W Powell
Aug 1, 1978·Journal of Clinical Pathology·M D BarnettD L Mollin
Jan 1, 1988·Annals of the New York Academy of Sciences·J W Halliday, L W Powell
Feb 1, 1989·European Journal of Haematology·T M Cox, D K Lord
Jan 1, 1979·CRC Critical Reviews in Clinical Laboratory Sciences·M Worwood

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