Alterations in transforming growth factor-alpha and epidermal growth factor receptor expression during rat esophageal tumorigenesis

Molecular Carcinogenesis
Q S WangGary D Stoner

Abstract

Transforming growth factor-alpha (TGF-alpha) stimulates cell proliferation through interaction with its receptor, the epidermal growth factor receptor (EGFR), by activating its tyrosine kinase activities. The simultaneous overexpression of TGF-alpha and EGFR by tumor cells is thought to trigger the autocrine growth pathway, leading to uncontrolled proliferation. To examine their roles in rat esophageal tumorigenesis induced by the chemical carcinogen N-nitrosomethylbenzylamine (NMBA), TGF-alpha, and EGFR expression was evaluated in normal rat esophageal epithelium, in NMBA-induced preneoplastic lesions, and in papillomas by quantitative reverse transcription-polymerase chain reaction (RT-PCR), in situ hybridization, and immunohistochemical analyses. Compared with the levels in normal epithelium, the TGF-alpha and EGFR mRNA levels in esophageal papillomas were 3.6 and 1.9 times higher, respectively. In the preneoplastic epithelium, although a trend of increased TGF-alpha and EGFR mRNA levels was observed, collectively there were no significant differences between preneoplastic and normal samples by RT-PCR analysis. In situ hybridization and immunohistochemical staining showed increased levels of TGF-alpha and EGFR mRNA and prote...Continue Reading

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Citations

Oct 13, 2006·Journal of Cancer Research and Clinical Oncology·Xiao Tang YuShi Lun Lu
Dec 11, 2002·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y Koak, M Winslet
Aug 9, 2002·Journal of Toxicology and Environmental Health. Part a·Rajaram GopalakrishnanGary D Stoner
Aug 15, 2000·Molecular Carcinogenesis·Q S WangD W Rosenberg
Oct 27, 2017·Acta chirurgica Belgica·Laura Christina LandesInes Gockel
Aug 6, 1998·The British Journal of Surgery·A M Sammon, D Alderson

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