Sep 1, 1994

Alterations in vascular pattern of the developing palate in normal and spontaneous cleft palate mouse embryos

The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
N AminY Takano

Abstract

The alterations in the vascularization of the developing palate were studied through the use of resin cast images of vascular networks in normal and spontaneous cleft lip and palate (CL/Fr) mouse embryos (crown rump [CR] Length 9-18 mm, body wt. 0.11-0.65 g). A more dense vascular plexus was observed in the oral side than in the nasal side before the reorientation of the palatal shelves. Prominent terminal dilatations of the vascular plexus were observed in the extreme medial edge of the elevating palatal shelves which may exert significant force for palatal shelf elevation. The vascular plexus showed a lateral extension. Many small spherical masses of resin were observed in the medial edge of the palatal shelves at the time of medial extension and during fusion, indicating some changes occurring in the capillary wall leading to the resin leakage. In the spontaneous cleft group, a similar vascular pattern was observed, but the greater palatine artery showed discontinuity in the premaxillary region at an early stage. At the same time, terminal dilatations were delayed and frequently absent in the contralateral shelf. After the reorientation of the palatal shelves, the vascular plexus formed an irregular lattice pattern. Dilated ...Continue Reading

Mentioned in this Paper

Embryo
Exertion
Embryo Loss
Structure of Papilla Incisiva of Mouth
Greater Palatine Artery
Extravasation
Blood Vessel
Cleft Palate, Isolated
Pathological Dilatation
Vascular Plexus

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