Alterations in white matter volume and integrity in obesity and type 2 diabetes

Metabolic Brain Disease
Liselotte van BloemendaalEelco van Duinkerken

Abstract

Type 2 diabetes mellitus (T2DM) is characterized by obesity, hyperglycemia and insulin resistance. Both T2DM and obesity are associated with cerebral complications, including an increased risk of cognitive impairment and dementia, however the underlying mechanisms are largely unknown. In the current study, we aimed to determine the relative contributions of obesity and the presence of T2DM to altered white matter structure. We used diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) to measure white matter integrity and volume in obese T2DM patients without micro- or macrovascular complications, age- gender- and BMI-matched normoglycemic obese subjects and age- and gender-matched normoglycemic lean subjects. We found that obese T2DM patients compared with lean subjects had lower axial diffusivity (in the right corticospinal tract, right inferior fronto-occipital tract, right superior longitudinal fasciculus and right forceps major) and reduced white matter volume (in the right inferior parietal lobe and the left external capsule region). In normoglycemic obese compared with lean subjects axial diffusivity as well as white matter volume tended to be reduced, whereas there were no significant differences between norm...Continue Reading

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Clinical Trials Mentioned

NCT01281228

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
FMRIB
DARTEL ( Diffeomorphic Anatomical Registration Through Exponen...
FSL
DARTEL
Statistical Parametric Mapping
Diffusion Toolbox of FMRI s Software Library ( FSL )
FMRIB58FA

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