Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health

Amino Acids
Yusheng LiGuanghua Lei

Abstract

Osteoarthritis (OA) is a common form of arthritis in humans. It has long been regarded as a non-inflammatory disease, but a degree of inflammation is now recognized as being a vital inducer of subpopulation of OA. Besides inflammation, the establishment and development of OA are associated with alterations in metabolism and profiles of amino acids (AA), including glutamate- and arginine-family AA as well as their related metabolites (e.g., creatinine, hydroxyproline, γ-aminobutyrate, dimethylarginines and homoarginine). Functional AA (e.g., glutamine, arginine, glutamate, glycine, proline, and tryptophan) have various benefits (i.e., anti-inflammation and anti-oxidation) in treatment of inflammation-associated diseases, including OA. Thus, these AA have potential as immunomodulatory nutrients for patients with inflammation-induced OA.

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Citations

Sep 10, 2016·Mediators of Inflammation·Yusheng LiGuanghua Lei
Aug 17, 2018·Foot & Ankle International·Elizabeth M LeimerSamuel B Adams
Jan 6, 2019·Annals of the Rheumatic Diseases·Wan-Su ChoiJang-Soo Chun
Nov 20, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christie A CostelloGuangju Zhai
Apr 21, 2017·Frontiers in Immunology·Yu-Sheng LiGuang-Hua Lei
Jul 18, 2020·Veterinary Sciences·Michela CintioBruno Stefanon
Apr 15, 2019·Aging Clinical and Experimental Research·Osvaldo Daniel MessinaLuis F Vidal Neira
Sep 29, 2020·Frontiers in Endocrinology·Marloes Dekker NitertBarbora de Courten
Nov 22, 2020·Clinical Rheumatology·Jie-Ting LiGuo-Xin Ni
Jan 24, 2019·Heliyon·Marta Anna SzychlinskaGiuseppe Musumeci
Jan 1, 2021·Ageing Research Reviews·Linli ZhengAli Mobasheri
Jan 29, 2021·Arthritis Research & Therapy·Xiaoxia HaoTao Xu

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