Alterations of amphetamine elicited perseveration and locomotor excitation following acute and repeated stressor application

Pharmacology, Biochemistry, and Behavior
B HahnH Anisman

Abstract

The effects of acute and repeated stressor application on amphetamine-induced Y-maze perseveration and locomotor activity were assessed. When the stimulus context associated with an acute stressor (restraint or restraint plus shock) was distinctively different from that in which an amphetamine test was conducted 72 hr afterward, neither perseveration nor locomotor excitation were augmented. However, following three restraint sessions the amphetamine elicited perseveration was enhanced. With a more protracted regimen applied over 15 days the augmented perseveration was absent, whereas the amphetamine-provoked motor excitation was increased. While stimulus factors have been shown to be fundamental, it is provisionally suggested that the stressor induced enhancement of amphetamine-elicited perseveration is influenced by sensitization processes. However, the sensitization is apparent only under some stress regimens, and the behavioral expression of the sensitization may be obfuscated if the stressor is too severe. Furthermore, it appears that the mechanisms operative in enhancing the stressor provoked amphetamine motor excitation are independent of those which subserve the augmented perseveration.

References

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Citations

Feb 14, 2007·Psychopharmacology·Jasmine J Yap, Klaus A Miczek
Aug 23, 2002·Behavioural Brain Research·Capriles Nancy del RosarioLiliana Marina Cancela
Nov 17, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A ZagoC S Planeta
Jan 1, 2008·Drug Discovery Today. Disease Models·Jasmine J Yap, Klaus A Miczek
Dec 30, 2008·Neuroscience and Biobehavioral Reviews·Andrew Holmes, Cara L Wellman
Oct 3, 2013·Pharmacology, Biochemistry, and Behavior·Darakhshan Jabeen HaleemMuhammad Abdul Haleem
Feb 15, 2012·Pharmacology, Biochemistry, and Behavior·Rodrigo Molini LeãoCleopatra da Silva Planeta
May 29, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Elham CharmchiAbbas Haghparast
Jun 19, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric A StoneDavid Quartermain
Nov 11, 2009·Brain Research·Lisa A Briand, Julie A Blendy

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