Alterations of angiotensin II receptor contents in hypertrophied hearts

Biochemical and Biophysical Research Communications
N FujiiK Murakami

Abstract

Tsukuba hypertensive mice, which carry the human genes for renin and angiotensinogen, show cardiac hypertrophy as well as hypertension due to activation of the renin-angiotensin system (RAS). Here, we compared the cardiac angiotensin II (Ang II) receptor contents in these and normotensive control mice by means of ligand binding studies and competitive reverse transcription-polymerase chain reaction analyses. The content of the Ang II receptor type 1 (AT1) was significantly higher at both the protein (2.5-fold; p < 0.01) and mRNA (1.4-fold; p < 0.05) levels in the hypertensive mice than that in control mice. Almost identical levels of the Ang II receptor type 2 (AT2) expression were identified at the mRNA levels in the two types of mice, although the levels were less than 20% of those of AT1 mRNA in control mice. These results suggest that AT1 in the heart is upregulated in response to Ang II-induced hypertrophic change and that, in particular, the upregulation of AT1 in particular contributes to the development and/or maintenance of cardiac hypertrophy in conjunction with the increase in Ang II production, because AT1 is responsible for cardiac hypertrophy related to the RAS.

Citations

Mar 29, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroaki MukawaTakayuki Ito
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·P ParadisM Nemer
May 20, 1998·Clinical and Experimental Pharmacology & Physiology·Y SumidaM Ishii
Apr 28, 2012·Cardiovascular Drugs and Therapy·Hiroshi AkazawaIssei Komuro
Dec 25, 2007·Life Sciences·Elise RousselMarie Arsenault
Jun 28, 2005·Pulmonary Pharmacology & Therapeutics·Hsiu-Wen ChanWalter G Thomas
Jun 5, 1998·The American Journal of Physiology·N FujiiH Miyazaki
Jan 14, 1999·The American Journal of Physiology·E KotaniH Miyazaki
May 1, 1999·Biochemical and Biophysical Research Communications·M TanakaT Inagami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.