Alterations of APC, c-met, and p53 genes in tumor tissue and serum of patients with gastric cancers

The Journal of Surgical Research
Jaw-Yuan WangShiu-Ru Lin

Abstract

Gastric cancer is one of the most significant causes of cancer-related death worldwide. A genetic model consisting of sequential accumulations of alterations in specific genes for gastric cancer has been proposed. The significance of adenomatous polyposis coli (APC) and p53 gene mutations in cancer tissues and their paired serum of 34 gastric cancer patients was investigated using polymerase chain reaction single-strand conformation polymorphism analysis (PCR-SSCP), followed by direct sequencing. c-met mRNA expression was evaluated by reverse-transcription PCR (RT-PCR). Additionally, analyses were carried out to detect the serum carcinoembryonic antigen (CEA) levels, and their correlation to these three molecular markers. Finally, serum molecular markers and their correlation to the presence of postoperative recurrence/metastasis were analyzed. Of all, 32.4% of patients presented mutations in APC and p53, respectively, and 58.8% presented the overexpression in c-met, overall, at least one of these genetic alterations in 79.4% of tumor tissues. Comparison of three molecular markers showed that the individual detection rate in the serum of patients with tumors harboring the same abnormalities was 18.2, 70.0, and 36.4% for APC, c-...Continue Reading

References

Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·E Tahara
Aug 3, 2000·International Journal of Epidemiology·A A BotterweckP A van Den Brandt
May 30, 2001·Cancer Genetics and Cytogenetics·R SudJ D Delhanty

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Citations

May 2, 2009·Clinical and Experimental Medicine·David Siu
Oct 8, 2004·Pharmacogenomics·Stacy H Shoshan, Arie Admon
Jun 10, 2010·Folia Histochemica Et Cytobiologica·Iwona GisterekJan Kornafel
Jul 21, 2011·World Journal of Clinical Oncology·Oscar J CorderoF Javier Rodriguez-Berrocal
Nov 16, 2006·Annals of Surgical Oncology·Alberto MarchetDonato Nitti
Jun 15, 2010·Cancer Epidemiology·Angela Rosa AndréSílvia Helena Barem Rabenhorst
Oct 20, 2009·Cancer Genetics and Cytogenetics·Mariana Ferreira LealRommel Rodríguez Burbano
Sep 26, 2006·Best Practice & Research. Clinical Gastroenterology·Matti VauhkonenPentti Sipponen
Jul 11, 2006·Critical Reviews in Oncology/hematology·Mukesh Verma, Upender Manne
Dec 16, 2016·Expert Opinion on Drug Safety·Yukiya Narita, Kei Muro
Apr 9, 2009·Biomedit︠s︡inskai︠a︡ khimii︠a︡·E P ElistratovaE Iu Rykova
May 17, 2005·Expert Review of Proteomics·Stacy H Shoshan, Arie Admon
Sep 13, 2019·Critical Reviews in Clinical Laboratory Sciences·Fatemeh MoosaviOmidreza Firuzi
Oct 18, 2019·Molecular and Clinical Oncology·Tomoaki ItoKoichi Sato
Sep 10, 2015·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O E Bryzgunova, P P Laktionov
Jun 1, 2007·Current Protocols in Pharmacology·Susan Jones-Bolin, Bruce Ruggeri
Oct 14, 2016·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Yue-Wen GaoXi-Zeng Hui
Feb 27, 2021·Journal of Theoretical Biology·Chong YuJin Wang

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