Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats

PloS One
Klemencja Berghauzen-MaciejewskaKrystyna Ossowska

Abstract

Our recent study has indicated that a moderate lesion of the mesostriatal and mesolimbic pathways in rats, modelling preclinical stages of Parkinson's disease, induces a depressive-like behaviour which is reversed by chronic treatment with pramipexole. The purpose of the present study was to examine the role of brain derived neurotrophic factor (BDNF) signalling in the aforementioned model of depression. Therefore, we investigated the influence of 6-hydoxydopamine (6-OHDA) administration into the ventral region of the caudate-putamen on mRNA levels of BDNF and tropomyosin-related kinase B (trkB) receptor. The BDNF and trkB mRNA levels were determined in the nigrostriatal and limbic structures by in situ hybridization 2 weeks after the operation. Pramipexole (1 mg/kg sc twice a day) and imipramine (10 mg/kg ip once a day) were injected for 2 weeks. The lesion lowered the BDNF and trkB mRNA levels in the hippocampus [CA1, CA3 and dentate gyrus (DG)] and amygdala (basolateral/lateral) as well as the BDNF mRNA content in the habenula (medial/lateral). The lesion did not influence BDNF and trkB expression in the caudate-putamen, substantia nigra, nucleus accumbens (shell and core) and ventral tegmental area (VTA). Chronic imipramine...Continue Reading

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Citations

Aug 21, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xinming XieManxiang Li
Aug 16, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Min SunXiao-Min Wang
Sep 13, 2017·Journal of Sports Sciences·Michael F AlmeidaMerari F R Ferrari
May 30, 2017·Neural Regeneration Research·Tuane Bazanella SampaioSimone Pinton
Oct 31, 2020·Oxidative Medicine and Cellular Longevity·Amira Mohammed Ali, Hiroshi Kunugi
Aug 26, 2021·Molecular Neurobiology·E C D GonçalvesR C Dutra

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Methods Mentioned

BETA
sedation

Software Mentioned

Multi Gauge
BLAST
STATISTICA

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