Alterations of cardiac and lymphocyte beta- adrenoceptors in rat with chronic heart failure

Science in China. Series C, Life Sciences
P ZhangM Chen

Abstract

The alterations of cardiac and lymphocyte beta-adrenoceptors were observed in the rats with chronic heart failure produced by constriction of both abdominal aorta and renal artery. The results showed that beta(1)-adrenoceptor density and mRNA levels were increased, whereas these levels remained unchanged for beta(2). The concentrationcontractile response curve for isoproterenol was shifted m the right in cardiac atrium, whereas the concentration-CAMP accumulation response curve for isoproterenol in myocardium was not changed. The number of beta-adrenoceptom in blood lymphocyte was markedly reduced. Thus in the heart-failure rats the density of cardiac beta-adrenoceptor was increased accompanying reduced beta-adrenoceptormediated positive inotropic response, suggesting a post adenylate cyclase dysfunction or impaired contractile components. In contrast, the alteration of beta-adrenoceptor in lymphocyte is consistent with the reduced beta-adrenoceptor-mediated inotropic response in heart.

References

Nov 15, 1979·Biochimica Et Biophysica Acta·C J Limas
Sep 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·E N JubergP W Abel
Dec 1, 1985·The Journal of Clinical Investigation·D E VatnerC J Homcy
Jul 22, 1982·The New England Journal of Medicine·M R BristowE B Stinson
Oct 3, 1980·European Journal of Pharmacology·G J Gross, M Gharaibeh

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