Alterations of cell lipids by metal salts

Journal of Biomedical Materials Research. Part a
G S Schuster, G B Caughman

Abstract

Metallic medical devices undergo degradation in vivo and the degradation products affect the chemistry and biological responses of cells and tissues in the immediate vicinity. The responses vary with the metal and cell type. In the current study, we examined the effects of several metals on a human monocytic cell line. Monocytes are important effector cells capable of responding rapidly to inflammatory and immune stimuli in a variety of ways, including production of inflammatory proteins, differential expression of surface adhesion molecules, enhanced phagocytic activity, and activation and differentiation to macrophages. Cells were exposed in the presence of (14)C-acetate to titanium, nickel, chromium, copper, or cobalt or vanadium at concentrations that were subinhibitory or inhibitory based on cellular mitochondrial dehydrogenase activity. Cell lipids were then extracted, separated by thin layer chromatography, and quantitated by liquid scintillation spectrometry. Total cell protein also was measured. Titanium reduced cell protein content at concentrations that were noninhibitory to mitochondrial dehydrogenase activity, whereas neither chromium nor cobalt affected protein amounts at dehydrogenase-inhibitory concentrations. I...Continue Reading

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Citations

Jun 21, 2011·Journal of Occupational and Environmental Medicine·Angela GambelungheGiacomo Muzi
Sep 28, 2010·Journal of Biomedical Materials Research. Part a·Dieter CadoschLuis Filgueira
Oct 8, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dieter CadoschLuis Filgueira
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Aug 11, 2007·Journal of Biomedical Materials Research. Part a·A MichiardiF J Gil
Mar 1, 2009·Metallomics : Integrated Biometal Science·Erwin Ph ChanLuis Filgueira
Aug 8, 2008·Critical Reviews in Toxicology·Hermine Dika NgueaBertrand Rihn
Apr 24, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Alireza AniHassan Ahmadvand

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