Alterations of cell surface antigens induced by placental isoform of ferritin in human carcinoma cell lines

Cancer Letters
J SedlakC Moroz

Abstract

the ability of the breast cancer-associated placental acid isoform of ferritin (p43-PLF) to modulate cell surface expression of HLA, CD59 (protectin) and CD66 antigen (adhesion antigen related to CEA) was examined. the expression of these antigens in human breast carcinoma cell lines BT-20, T47D and MDA-MB-468 was determined with the aid of flow cytometry and monoclonal antibodies. PLF induced a transient up-regulation followed by a down regulation of cell surface protectin (CD59 antigen) on the cell surface of T47D and to a lesser extent, BT-20 human breast carcinoma cell lines. Furthermore, PLF down-regulated cell surface expression of CEA-related CD66 antigen on both these cell lines. No PLF-induced alterations of protectin, CD66 antigen and HLA class I antigen were found on the MDA-MB-468 breast cancer cell line. breast cancer-associated p43 induces alterations of the expression of cell surface molecules in breast cancer cells which could have an effect on the modulation of cancer cell adhesive interactions.

References

Jul 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I T Young
Sep 9, 1992·International Journal of Cancer. Journal International Du Cancer·H R RosenM Eibl
Jan 1, 1991·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·N ShtermanC Moroz
May 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·C MorozB Parhami-Seren

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Citations

Jan 1, 1996·Breast Cancer Research and Treatment·H R RosenC Moroz
Sep 17, 2003·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiaoyan XuHanping Chen
Jul 3, 2013·European Journal of Medicinal Chemistry·Alessandra TolomelliMargarita Escudero

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