Alterations of cerebellar mRNA specific for BDNF, p75NTR, and TrkB receptor isoforms occur within hours of ethanol administration to 4-day-old rat pups

Brain Research. Developmental Brain Research
Yun GeK E Light

Abstract

Developing cerebellar Purkinje cells of the rat are extremely sensitive to ethanol during postnatal days (PN) 4-6, but not at later times during development. Ethanol exposure during this vulnerable window induces rapid apoptotic Purkinje cell death that is hypothesized to result from ethanol inhibition in brain-derived nerve growth factor (BDNF)-TrkB neurotrophic signaling that results in loss of apoptotic suppression. In this study, the effect that different concentrations of ethanol (1.5, 3.0, 4.5 and 6.0 g/kg) have on steady-state mRNA expression of BDNF and different TrkB receptor isoforms in the cerebellum on PN4 was determined at 1, 4, 6, and 8 h after treatment. Significant decreases in mRNA specific for BDNF and TrkB isoforms were detected within 1 h after ethanol administration. No significant alterations in expression of mRNA specific to the low affinity p75(NTR) receptor were identified. These alterations are concurrent with the PN4 vulnerable period for Purkinje cells since equivalent treatment of PN9 rat pups does not produce significant alterations in mRNA specific to BDNF or TrkB at 4 h after exposure. These results support the hypothesis that ethanol induces a disruption of BDNF-TrkB signaling that results in lo...Continue Reading

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Citations

Apr 17, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Verónica BalaszczukCarlos A Beltramino
Jun 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dongxiao SunMing D Li
Jan 5, 2011·Neuroscience and Biobehavioral Reviews·Diane Dufour-RainfrayChristian R Andres
Apr 9, 2008·Pharmacology & Therapeutics·Margaret I Davis
Nov 23, 2005·Neurotoxicology and Teratology·Diana EcheverriaClaire Garabedian
Aug 10, 2007·Journal of Applied Toxicology : JAT·Vittorio FattoriRyozo Tsuji
Jan 6, 2018·Neurotoxicity Research·Yousef TizabiRobert E Taylor
Jun 16, 2005·Experimental Biology and Medicine·Charles R GoodlettFeng C Zhou

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