Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease

Scientific Reports
Ya-Fang ChenShun-Chung Yang

Abstract

Patients with asymptomatic occlusion in the internal carotid arteries (ICA) have been shown to have a better preserved hemodynamic status of the brain as compared to patients with symptoms. This study was aimed to explore the cerebral perfusion alterations in asymptomatic patients using multi-parametric arterial spin-labeling (ASL) magnetic resonance (MR) imaging. Forty-two patients diagnosed with asymptomatic ICA stenosis/occlusion were prospectively included and divided into high-grade (ultrasonographic stenosis ≥70%, N = 20) and low-grade groups (N = 22). On a 3-Tesla clinical MR scanner, pseudo-continuous ASL was performed to measure cerebral blood flow CBF, arterial transit time ATT, and flow territory. Fisher's exact test indicates that the high-grade group has higher frequency in asymmetric ATT (p < 10-3) and asymmetric flow territory (p < 10-3) as compared to the low-grade group. The between-group difference in CBF asymmetry is marginal (p = 0.062). Logistic regression further reveals that hemispherical asymmetry in ATT and flow territory is associated with the existence of high-grade ICA stenosis (odds ratio = 12 and 21, respectively), whereas hemispherical asymmetry in CBF is not. Our data suggest that ATT and flow te...Continue Reading

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Citations

Jan 29, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alexander SeilerMarlies Wagner
Sep 13, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fanny QuandtGötz Thomalla
Sep 1, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michele PorcuLuca Saba

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Methods Mentioned

BETA
imaging technique

Software Mentioned

Statistical Parametric Mapping
MATLAB

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