Alterations of coagulation in metformin intoxication

Hormones : International Journal of Endocrinology and Metabolism
Baris AkinciSena Yesil

Abstract

It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery. Our results indicate that both the levels of coagulation proteins synthesized by the liver and the anti-coagulant activity decrease temporarily in metformin intoxication. Nevertheless, no change in the coagulation factors secreted by the endothelium were observed.

Citations

Jun 9, 2016·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Suneel Kumar GargKirti Vashist
Aug 22, 2018·Journal of Intensive Care Medicine·George Sam Wang, Christopher Hoyte
Apr 11, 2015·Critical Care Medicine·Diane P CalelloUNKNOWN Extracorporeal Treatments in Poisoning Workgroup
Sep 15, 2017·Journal of the American College of Nutrition·Denise Tavares GianniniMoyses Szklo
Nov 5, 2020·Case Reports in Critical Care·Céline BellefroidMarine Deville

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