Alterations of collagen matrix in weight-bearing bones during skeletal unloading

Connective Tissue Research
Masashi ShiibaM Yamauchi

Abstract

Skeletal unloading induces loss of bone mineral density in weight-bearing bones. The objectives of this study were to characterize the post-translational modifications of collagen of weight-bearing bones subjected to hindlimb unloading for 8 weeks. In unloaded bones, tibiae and femurs, while the overall amino acid composition was essentially identical in the unloaded and control tibiae and femurs, the collagen cross-link profile showed significant differences. Two major reducible cross-links (analyzed as dihydroxylysinonorleucine and hydroxylysinonorleucine) were increased in the unloaded bones. In addition, the ratios of the former to the latter as well as pyridinoline to deoxypyridinoline were significantly decreased in the unloaded bones indicating a difference in the extent of lysine hydroxylation at the cross-linking sites between these two groups. These results indicate that upon skeletal unloading the relative pool of newly synthesized collagen is increased and it is post-translationally altered. The alteration could be associated with impaired osteoblastic differentiation induced by skeletal unloading that results in a mineralization defect.

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Citations

Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masashi ShiibaMitsuo Yamauchi
Dec 6, 2008·Folia Histochemica Et Cytobiologica·Hanna Trebacz, Krzysztof Wójtowicz
Nov 11, 2008·Connective Tissue Research·Kentaro TokutomiMitsuo Yamauchi
Oct 15, 2014·Journal of Prosthodontic Research·Masaru Kaku, Mitsuo Yamauchi
Oct 11, 2005·Muscle & Nerve·Constantinos N MaganarisArnold De Haan
Jan 30, 2007·PPAR Research·P J Marie, K Kaabeche
Sep 8, 2016·Acta Crystallographica. Section D, Structural Biology·Hong Wen ZhouLila Graham
Jun 22, 2017·Journal of Prosthodontic Research·Shinichiro KuroshimaTakashi Sawase

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