Alterations of DNA methylation in parathyroid tumors

Molecular and Cellular Endocrinology
Vito GuarnieriS Corbetta

Abstract

Parathyroid tumors are common endocrine neoplasias associated with primary hyperparathyroidism, a metabolic disorder characterized by parathormone hypersecretion. Parathyroid neoplasia are frequently benign adenomas or multiple glands hyperplasia, while malignancies are rare. The epigenetic scenario in parathyroid tumors has just begun to be decoded: DNA methylation, histones and chromatin modifiers expression have been investigated so far. The main findings suggest that DNA methylation and chromatin remodeling are active and deregulated in parathyroid tumors, cooperating with genetic alterations to drive the tumor phenotype: the tumor suppressors menin and parafibromin, involved in parathyroid tumorigenesis, interact with chromatin modifiers, defining distinct epigenetic derangements. Many epigenetic alterations identified in parathyroid tumors are common to those in human cancers; moreover, some aspects of the epigenetic profile resemble epigenetic features of embryonic stem cells. Epigenetic profile may contribute to define the heterogeneity of parathyroid tumors and to provide targets for new therapeutic approaches.

References

Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·T CarlingG Akerström

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Citations

May 5, 2018·Endocrine-related Cancer·Chiara VerdelliSabrina Corbetta
Nov 8, 2018·Endocrine-related Cancer·Xiang ZhangYupei Zhao
Mar 16, 2021·Frontiers in Endocrinology·Jenny E Blau, William F Simonds

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