Alterations of energy and substrate metabolism in rats with large and sustained changes in daily food intake

The American Journal of Physiology
J F Wang, H S Koopmans

Abstract

Energy expenditure was measured in one-way crossed-intestine rats by use of indirect calorimetry to examine the role of energy metabolism in body weight control. The intestinal surgery was done according to Koopmans (Brain Res. Bull. 14: 595-603, 1985). The food-losing rats increased daily food intake from 70.8 to 126.3 g/day, whereas their partners decreased intake from 67.1 to 38.7 g/day (P < 0.001). Compared with levels before surgery, the food-losing rats showed slightly increased O2 consumption (1.31 vs. 1.28 1.h-1.kg-1) and metabolic rate (6.62 vs. 6.39 kcal.h-1.kg-1) and largely increased CO2 production (1.31 vs. 1.22 l.h-1.kg-1, P < 0.01), whereas in their food-gaining partners O2 consumption (1.12 vs. 1.25 l.h-1.kg-1, P < 0.01) and metabolic rate (5.76 vs. 6.26 kcal.h-1.kg-1) were significantly decreased. Respiratory quotients were higher in the food-gaining rats than in their partners (1.076 vs. 0.999, P < 0.01), indicating more fatty acid synthesis. These results suggest that daily food intake and energy expenditure increase and decrease together, despite the fact that about the same amount of food has been absorbed from the intestines of each rat.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.