Abstract
The increased cardiovascular risk in RA (rheumatoid arthritis) cannot be explained by common quantitative circulating lipid parameters. The objective of the study was to characterize the modifications in HDL phosphosphingolipidome in patients with RA to identify qualitative modifications which could better predict the risk for CVD. Nineteen patients with RA were compared to control subjects paired for age, sex, BMI, and criteria of metabolic syndrome. The characterization of total HDL phosphosphingolipidome was performed by LC-MS/MS. RA was associated with an increased HDL content of lysophosphatidylcholine and a decreased content of PC (phosphatidylcholine), respectively, positively and negatively associated with cardiovascular risk. A discriminant molecular signature composed of 18 lipids was obtained in the HDL from RA patients. The detailed analysis of phospholipid species showed that molecules carrying omega-3 FA (fatty acids), notably docosahexaenoic acid (C22:6 n-3), were depleted in HDL isolated from RA patients. By contrast, two PE (phosphatidylethanolamine) species carrying arachidonic acid (C20:4 n-6) were increased in HDL from RA patients. Furthermore, disease activity and severity indexes were associated with alter...Continue Reading
References
Oct 9, 1999·The Journal of Biological Chemistry·C J DeLongZ Cui
Dec 17, 2003·Prostaglandins & Other Lipid Mediators·Mohamedain M Mahfouz, Fred A Kummerow
Oct 7, 2004·Journal of the American Society for Mass Spectrometry·Karin A Zemski Berry, Robert C Murphy
Feb 9, 2005·Circulation·Hok-Hay S OeiJacqueline C M Witteman
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew Zalewski, Colin Macphee
Jul 30, 2005·Arthritis and Rheumatism·Nicola J GoodsonAlan J Silman
Jul 19, 2006·Methods : a Companion to Methods in Enzymology·Stephen MilneH Alex Brown
Sep 2, 2006·Analytical Chemistry·Christer S EjsingAndrej Shevchenko
Nov 28, 2008·Arthritis and Rheumatism·J Antonio Aviña-ZubietaDiane Lacaille
Oct 31, 2009·Arthritis and Rheumatism·Mike J L PetersMichael T Nurmohamed
Jun 17, 2010·Annals of the Rheumatic Diseases·A G SembI Holme
Aug 12, 2010·Annals of the Rheumatic Diseases·Daniel AletahaGillian Hawker
Mar 1, 2010·Nutrients·Philip C Calder
Mar 20, 2012·Annals of the Rheumatic Diseases·Juan Antonio Avina-ZubietaDiane Lacaille
May 30, 2013·International Journal of Cardiology·Frédéric DutheilDaniel Courteix
Jun 19, 2013·Nature Reviews. Rheumatology·Jamie RobertsonNaveed Sattar
Sep 27, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Wijtske Annema, Arnold von Eckardstein
Oct 2, 2013·Annals of the Rheumatic Diseases·Susanna M ProudmanLeslie G Cleland
Oct 5, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Laurent CamontAnatol Kontush
Nov 5, 2013·Biochimica Et Biophysica Acta·Dennis E Vance
Dec 3, 2014·Atherosclerosis·Leonardo Gómez RossoAnatol Kontush
Feb 1, 2015·Journal of the American Heart Association·Katherine P LiaoNehal N Mehta
Oct 5, 2016·Annals of the Rheumatic Diseases·R AgcaM T Nurmohamed
Oct 11, 2016·Therapeutic Advances in Musculoskeletal Disease·Anne TournadreMartin Soubrier
Dec 15, 2016·Pilot and Feasibility Studies·Sandra M EldridgeUNKNOWN PAFS consensus group
May 26, 2018·Medicine·Amir Emamifar, Inger Marie Jensen Hansen
Citations
Jan 19, 2020·Nutrients·Kassandra LanchaisAnne Tournadre
Aug 4, 2020·PloS One·Laurette van BoheemenMichael T Nurmohamed
Apr 17, 2020·Frontiers in Cardiovascular Medicine·Anne Jomard, Elena Osto
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alan Dorantes-MoralesElizabeth Carreón-Torres
Feb 6, 2021·European Journal of Nutrition·Alexandre PinelFrédéric Capel
May 6, 2021·Cells·Fabrizia BonacinaGiuseppe D Norata
Jun 29, 2021·Frontiers in Molecular Biosciences·Haijun Zhao, Yanhui He