Alterations of HDL particle phospholipid composition and role of inflammation in rheumatoid arthritis.

Journal of Physiology and Biochemistry
Charlotte GiraudFrédéric Capel

Abstract

The increased cardiovascular risk in RA (rheumatoid arthritis) cannot be explained by common quantitative circulating lipid parameters. The objective of the study was to characterize the modifications in HDL phosphosphingolipidome in patients with RA to identify qualitative modifications which could better predict the risk for CVD. Nineteen patients with RA were compared to control subjects paired for age, sex, BMI, and criteria of metabolic syndrome. The characterization of total HDL phosphosphingolipidome was performed by LC-MS/MS. RA was associated with an increased HDL content of lysophosphatidylcholine and a decreased content of PC (phosphatidylcholine), respectively, positively and negatively associated with cardiovascular risk. A discriminant molecular signature composed of 18 lipids was obtained in the HDL from RA patients. The detailed analysis of phospholipid species showed that molecules carrying omega-3 FA (fatty acids), notably docosahexaenoic acid (C22:6 n-3), were depleted in HDL isolated from RA patients. By contrast, two PE (phosphatidylethanolamine) species carrying arachidonic acid (C20:4 n-6) were increased in HDL from RA patients. Furthermore, disease activity and severity indexes were associated with alter...Continue Reading

References

Dec 17, 2003·Prostaglandins & Other Lipid Mediators·Mohamedain M Mahfouz, Fred A Kummerow
Oct 7, 2004·Journal of the American Society for Mass Spectrometry·Karin A Zemski Berry, Robert C Murphy
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew Zalewski, Colin Macphee
Jul 19, 2006·Methods : a Companion to Methods in Enzymology·Stephen MilneH Alex Brown
Nov 28, 2008·Arthritis and Rheumatism·J Antonio Aviña-ZubietaDiane Lacaille
Mar 1, 2010·Nutrients·Philip C Calder
Mar 20, 2012·Annals of the Rheumatic Diseases·Juan Antonio Avina-ZubietaDiane Lacaille
Jun 19, 2013·Nature Reviews. Rheumatology·Jamie RobertsonNaveed Sattar
Sep 27, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Wijtske Annema, Arnold von Eckardstein
Nov 5, 2013·Biochimica Et Biophysica Acta·Dennis E Vance
Oct 11, 2016·Therapeutic Advances in Musculoskeletal Disease·Anne TournadreMartin Soubrier
Dec 15, 2016·Pilot and Feasibility Studies·Sandra M EldridgeUNKNOWN PAFS consensus group

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Citations

Jan 19, 2020·Nutrients·Kassandra LanchaisAnne Tournadre
Aug 4, 2020·PloS One·Laurette van BoheemenMichael T Nurmohamed
Apr 17, 2020·Frontiers in Cardiovascular Medicine·Anne Jomard, Elena Osto
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alan Dorantes-MoralesElizabeth Carreón-Torres

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Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assay

Software Mentioned

Stata
R

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