Alterations of HDL subclasses in hyperlipidemia

Clinica Chimica Acta; International Journal of Clinical Chemistry
Yanhua Xu, Mingde Fu

Abstract

It is generally accepted that different high-density lipoprotein (HDL) subclasses have distinct but interrelated metabolic functions. HDL is known to directly influence the atherogenic process and changes in HDL subclasses distribution may be related to the incidence and prevalence of atherosclerosis. The relative apolipoprotein (apo)A-I contents (% apoA-I) of plasma HDL subclasses were determined by two-dimensional gel electrophoresis coupled with immunodetection for apoA-I, in 39 hypercholesterolemic (HTC) subjects, 97 hypertriglyceridemic (HTG) subjects and 32 mixed hyperlipidemic (MHL) subjects, and 124 normolipidemic subjects. The relative apoA-I contents of prebeta(1)-HDL, prebeta(2)-HDL, HDL(3c), HDL(3b) and HDL(3a) significantly increased while HDL(2a) and HDL(2b) significantly decreased in hyperlipidemic subjects. In HTC subjects of hyperlipidemia, the concentrations of prebeta(1)-HDL were significantly lower and HDL(2b) concentrations were significantly higher than in HTG and MHL subjects. In HTG subjects, the concentrations of HDL(3a) were significantly higher and the concentrations of HDL(2b) were lower than in HTC and MHL subjects. In total hyperlipidemic subjects, plasma triglyceride (TG) concentrations showed pos...Continue Reading

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Citations

Jun 1, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lianqun JiaShiyin Long
Nov 3, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cynthia García-SánchezOscar Pérez-Méndez
Nov 27, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Li TianLianqun Jia
May 29, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lianqun JiaLi Tian
Mar 8, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yuye YangYing Tian
Apr 4, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michel R Langlois, Victor H Blaton
Mar 28, 2006·The Journal of Nutritional Biochemistry·Moises Torres-GonzalezMaria Luz Fernandez
Jun 1, 2006·Current Opinion in Colloid & Interface Science·J Bruce GermanAngela M Zivkovic
Dec 21, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shiyin LongMingde Fu
Nov 18, 2005·American Heart Journal·Lantu GouLuchuan Yang
Dec 3, 2014·Atherosclerosis·Konstantin A KrychtiukWalter S Speidl
Jun 15, 2012·Atherosclerosis·Patricia BlackburnJean-Pierre Després
Jan 1, 2004·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Michio Numata
May 27, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Weihong HuJie Qiao
May 22, 2013·Journal of Lipid Research·Nicola L HarmanIan G Davies
Jan 17, 2013·Stroke; a Journal of Cerebral Circulation·Choy-Lye CheiUNKNOWN CIRCS Investigators
Sep 15, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Xunde XianGeorge Liu

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