Alterations of host cell ubiquitination machinery by pathogenic bacteria

Frontiers in Cellular and Infection Microbiology
Jaafar AlomairiPhilippe Soubeyran

Abstract

Response of immune and non-immune cells to pathogens infections is a very dynamic process. It involves the activation/modulation of many pathways leading to actin remodeling, membrane engulfing, phagocytosis, vesicle trafficking, phagolysosome formation, aiming at the destruction of the intruder. These sophisticated and rapid mechanisms rely on post-translational modifications (PTMs) of key host cells' factors, and bacteria have developed various strategies to manipulate them to favor their survival. Among these important PTMs, ubiquitination has emerged as a major mediator/modulator/regulator of host cells response to infections that pathogens have also learned to use for their own benefit. In this mini-review, we summarize our current knowledge about the normal functions of ubiquitination during host cell infection, and we detail its hijacking by model pathogens to escape clearance and to proliferate.

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Citations

Jun 16, 2015·Frontiers in Cellular and Infection Microbiology·Benjamin CoiffardEric Ghigo
Oct 9, 2018·Frontiers in Physiology·Aarti SinghMichelangelo Campanella
Jul 3, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Megumi TsuchiyaTokuko Haraguchi
Aug 24, 2021·Current Opinion in Immunology·Margaret M McDanielChandrashekhar Pasare
Aug 31, 2021·Frontiers in Immunology·Vanitha MariappanJamuna Vadivelu

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Methods Mentioned

BETA
ubiquitination
two hybrid
nucleotide exchange

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