Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment

Frontiers in Oncology
Lara P FernándezAna Ramírez de Molina

Abstract

Cancer remains the second leading cause of mortality worldwide. In the course of this multistage and multifactorial disease, a set of alterations takes place, with genetic and environmental factors modulating tumorigenesis and disease progression. Metabolic alterations of tumors are well-recognized and are considered as one of the hallmarks of cancer. Cancer cells adapt their metabolic competences in order to efficiently supply their novel demands of energy to sustain cell proliferation and metastasis. At present, there is a growing interest in understanding the metabolic switch that occurs during tumorigenesis. Together with the Warburg effect and the increased glutaminolysis, lipid metabolism has emerged as essential for tumor development and progression. Indeed, several investigations have demonstrated the consequences of lipid metabolism alterations in cell migration, invasion, and angiogenesis, three basic steps occurring during metastasis. In addition, obesity and associated metabolic alterations have been shown to augment the risk of cancer and to worsen its prognosis. Consequently, an extensive collection of tumorigenic steps has been shown to be modulated by lipid metabolism, not only affecting the growth of primary tu...Continue Reading

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Citations

Mar 7, 2021·International Journal of Molecular Sciences·Rola El SayedAli Shamseddine
Apr 4, 2021·Biology·Ji-Yoon LeeEun-Woo Lee
Jul 3, 2021·International Journal of Molecular Sciences·Aleksandra HliwaTomasz Sledzinski
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Parichart TesenaAttawit Kovitvadhi
Jul 3, 2021·International Journal of Molecular Sciences·Miljana NenkovYuan Chen
Aug 26, 2021·Journal of Experimental & Clinical Cancer Research : CR·Francesca AscenziRita Mancini
Oct 27, 2021·Biomolecules & Therapeutics·Vijayakumar Natesan, Sung-Jin Kim
Nov 2, 2021·Medicinal Research Reviews·Prema K AgarwalaShobhna Kapoor
Nov 3, 2021·Critical Reviews in Clinical Laboratory Sciences·Sarahi Jaramillo OrtizFrédéric J Tessier

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Methods Mentioned

BETA
xenografts

Clinical Trials Mentioned

ISRCTN99660610
NCT03808558
NCT03179904
NCT03032484
NCT02223247
NCT02856555
NCT01992042
NCT00608595
NCT00994903
NCT00452244

Software Mentioned

Pathology Atlas
ColoLipidGene

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