Alterations of maternal and fetal leptin concentrations in hypertensive disorders of pregnancy

European Journal of Obstetrics, Gynecology, and Reproductive Biology
N VitoratosG Creatsas

Abstract

To investigate whether hypertensive disorders of pregnancy alter the maternal and fetal leptin levels. Fifty primigravidas between 28 and 34 weeks of gestation were divided into three groups: group A consisted of 17 normal pregnant women with a mean gestational age of 31 weeks, group B consisted of 15 women with gestational hypertension without proteinuria with a mean gestational age of 30 weeks and group C consisted of 18 pre-eclamptic women with a mean gestational age of 31 weeks. The pre-eclamptics had significantly higher serum leptin levels than those in normal pregnancies (p<0.001) but no difference was noted between normal and gestational hypertensive pregnancies. Pre-eclamptic women had significantly higher umbilical vein leptin levels (4.68+/-1.66ng/ml) compared to normal pregnancies (1.92+/-0.71ng/ml) and those with gestational hypertension (2.47+/-0.81ng/ml). Pre-eclampsia is associated with an increase in maternal plasma leptin levels and fetal of leptin production increases in gestational hypertension and even more in pre-eclampsia.

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Citations

Jul 31, 2009·Current Diabetes Reports·Dimitrios S MastrogiannisCarol J Homko
Jun 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sebiha OzkanKiliç Aydinli
Apr 16, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Te-Fu ChanShyng-Shiou F Yuan
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Apr 3, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Yildiz AtamerAytaç Atamer
Apr 6, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Kai J BuhlingJoachim W Dudenhausen
Jan 13, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sahin ZeterogluHuseyin A Sahin
Sep 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sahin ZeterogluHuseyin Avni Sahin
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