Alterations of maternal serum and placental follistatin-like 3 and myostatin in pre-eclampsia

The Journal of Obstetrics and Gynaecology Research
Jing GuoMinyue Dong

Abstract

To clarify the alterations of myostatin, a member of the transforming growth factor-β superfamily, and follistatin-like 3 (FSTL3), a binding protein for myostatin, in pre-eclamptic women. Samples of blood and placenta were collected from 40 pre-eclamptic women and 40 controls. The serum level and placental expression of FSTL3 and myostatin were determined with enzyme-linked immunosorbent assay, real-time polymerized chain reaction and western blotting. The serum levels of myostatin and FSTL3 were significantly higher in pre-eclamptic women than in the controls (P < 0.001 for both). Placental expression of myostatin and FSTL3 were also significantly increased in the pre-eclamptic placenta compared with that of the controls (P < 0.001 for both); however, there were no significant differences in myostatin or FSTL3 in either the maternal serum or the placenta in women with mild or severe pre-eclampsia (P > 0.05 for both). The serum levels and placental expression of myostatin and FSTL3 are elevated in pre-eclampsia, suggesting the role of myostatin and its binding protein in pre-eclampsia.

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Citations

Nov 14, 2013·BMC Medical Genomics·Eduardo TejeraIrene Rebelo
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Jan 27, 2019·Experimental and Therapeutic Medicine·Haldun Arpaci
Oct 2, 2017·Metabolism: Clinical and Experimental·Jaana NevalainenMarkku Ryynanen

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