PMID: 9171945Jun 1, 1997Paper

Alterations of mRNA levels of alpha 1-adrenoceptor subtypes with maturation and ageing in different rat blood vessels

Clinical and Experimental Pharmacology & Physiology
K M XuC Han

Abstract

1. Alterations of mRNA levels of alpha 1-adrenoceptor subtypes during maturation and ageing were determined by reverse transcription-polymerase chain reaction (RT-PCR) in aortae and renal, pulmonary and mesenteric arteries isolated from 3, 12 and 24-month-old rats. 2. The steady state levels for alpha 1A-, alpha 1B- and alpha 1D-adrenoceptors in aorta declined with maturation and ageing. In renal artery there was a decrease in mRNA for the alpha 1B-adrenoceptor in aged rats. However, in mesenteric and pulmonary arteries there were no changes in mRNA levels for the three subtypes of alpha 1-adrenoceptors as a result of maturation and ageing. 3. The results suggest that expression of alpha 1-adrenoceptors is changed heterogeneously in different blood vessels during maturation and ageing in rats.

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Citations

Mar 27, 2004·European Journal of Pharmacology·Sven JähnichenHeinz H Pertz
Apr 27, 2000·European Journal of Pharmacology·M B Hussain, I Marshall
May 5, 2001·Pharmacology & Therapeutics·G A MichelottiD A Schwinn
Jun 24, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Christopher J ClarkeJacqueline Ohanian
Jul 2, 2009·Autonomic & Autacoid Pharmacology·J H Gómez-Zamudio, R Villalobos-Molina
Dec 19, 2012·The Journal of Physiology·Erika B Westcott, Steven S Segal

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