Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer.

Frontiers in Cellular and Infection Microbiology
Qiaofei ZhaoBaoyong Wang

Abstract

Emerging evidence supports that oral microbiota are associated with health and diseases of the esophagus. How oral microbiota change in Chinese patients with esophageal cancer (EC) is unknown, neither is their biomarker role. For an objective to understand alterations of oral microbiota in Chinese EC patients, we conducted a case-control study including saliva samples from 39 EC patients and 51 healthy volunteers. 16S rDNA genes of V3-V4 variable regions were sequenced to identify taxon. Relationship between oral flora and disease was analyzed according to alpha diversity and beta diversity. Resultantly, the Shannon index (p = 0.2) and the Simpson diversity index (p = 0.071) were not significant between the two groups. Yet we still found several species different in abundance between the two groups. For the EC group, the most significantly increased taxa were Firmicutes, Negativicutes, Selenomonadales, Prevotellaceae, Prevotella, and Veillonellaceae, while the most significantly decreased taxa were Proteobacteria, Betaproteobacteria, Neisseriales, Neisseriaceae, and Neisseria. In conclusion, there are significant alterations in abundance of some oral microbiomes between the EC patients and the healthy controls in the studied Ch...Continue Reading

References

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Citations

Aug 28, 2021·Microorganisms·Yukiko YanoChristian C Abnet
Oct 5, 2021·Frontiers in Cellular and Infection Microbiology·Zhengqi LiGuiqi Wang

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Methods Mentioned

BETA
dissection
biopsy
PCR
electrophoresis

Software Mentioned

USEARCH
QIIME
ANOSIM
R stats package
R
R language stats package
LEfSe
PANDAseq
UniFrac

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