Alterations of p16 and p15 genes in acute leukemia with MLL gene rearrangements and their correlation with clinical features

Leukemia
H OhnishiY Hayashi

Abstract

p16 and p15 genes are putative tumor suppressor genes located on chromosome 9p21. In acute leukemias, alterations of p16 and p15 genes have been reported to occur exclusively in lymphoid lineage. We analyzed alterations of p16 and p15 genes in 46 acute leukemias with MLL gene rearrangements by Southern blot analysis, and investigated the association with clinical characteristics. We identified homozygous deletion of p16 and p15 genes in five (19%) of 27 acute lymphoblastic leukemias (ALLs) and in two (11%) of 19 acute myeloid leukemias (AMLs). Patients with homozygous deletion of p16 and p15 genes showed higher average leukocyte counts (343 x 10(9)/l vs 271 x 10(9)/l) and lower estimated 2-year survival rates than those with normal p16 and p15 genes (14.3 vs 30.7%), although the differences were not statistically significant. In addition, we investigated mutation of p16 gene by polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) in 31 patients, but no mutation was found in the patients tested. Our results suggest that alterations of p16 and p15 genes are involved in a subset of acute leukemias with MLL gene rearrangement not only of lymphoid but also of myeloid phenotype. Homozygous deletion of p16 and ...Continue Reading

Citations

Sep 28, 2006·BMC Cancer·Katrin HoffmannUrsula R Kees
Jan 26, 2007·Leukemia Research·Lisa M Baumann KreuzigerDavid P Steensma
Jul 18, 2006·Cancer Genetics and Cytogenetics·Christopher StasikDiane L Persons
Jul 21, 2004·Cancer Genetics and Cytogenetics·Cristina MorerioClaudio Panarello
Mar 31, 2005·Cancer Genetics and Cytogenetics·Ken-Ichiro KobayashiNaoki Kakazu
Feb 2, 2010·Cancer Genetics and Cytogenetics·Joana SantosManuel R Teixeira
May 29, 2002·Oncogene·Utz KrugH Phillip Koeffler
Aug 2, 2003·Oncogene·Tessy T MaliekalDevarajan Karunagaran
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Mar 6, 2003·Oncogene·Martin U KueferStephan W Morris
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Dec 12, 2001·Molecular and Cellular Biology·Xiao-Rong PengWilliam S Trimble
Jun 11, 1999·International Journal of Cancer. Journal International Du Cancer·H W YangY Hayashi

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