Alterations of penicillin-binding proteins 1A, 2X, and 2B in Streptococcus pneumoniae isolates for which amoxicillin MICs are higher than penicillin MICs

Antimicrobial Agents and Chemotherapy
K KosowskaPeter C Appelbaum

Abstract

Penicillin-binding proteins (PBPs) of 15 selected penicillin- and amoxicillin-resistant Streptococcus pneumoniae isolates (MICs of 2 to 8 and 8 to 16 microg/ml, respectively) were studied. In addition to typical changes in PBPs 1A and 2X, these strains had 10 unique changes in PBP 2B, including a (618)A-G substitution, which may be the key alteration associated with amoxicillin resistance.

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Citations

Nov 30, 2000·Current Infectious Disease Reports·M R Jacobs, P C Appelbaum
Mar 3, 2010·Antimicrobial Agents and Chemotherapy·Ewa SadowyWaleria Hryniewicz
Mar 25, 2009·Antimicrobial Agents and Chemotherapy·Klaudia Kosowska-ShickPeter C Appelbaum
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