PMID: 8944666Nov 1, 1996Paper

Alterations of plasma lactate and glucose metabolism in obese children

The American Journal of Physiology
C L Stunff, P F Bougnères

Abstract

Using a double stable isotope infusion method, we quantified plasma glucose and lactate inter-relationships in five recently obese children. Compared with five age-matched controls, obese children had an approximately 50% increase of total body lactate turnover [167 +/- 20 vs. 111 +/- 20 (SE) mg/min, P < 0.05]. The rate of lactate conversion to glucose was double the normal rate (96 +/- 21 vs. 46 +/- 10 mg/min, P < 0.05). Increased gluconeogenesis from plasma lactate correlated with total glucose production (r = 0.74), with plasma lactate contributing to 58% of glucose production in obese children vs. 38% in normal children (P < 0.05). Conversion into glucose correlated with the rate of lactate release in the circulation (r = 0.76). In turn, the obese children converted a larger fraction (35 +/- 2 vs. 27 +/- 2%, P < 0.02) and amount (58 +/- 10 vs. 34 +/- 5 mg/min, P < 0.05) of glucose into plasma lactate. The amount of lactate originating from plasma glucose correlated (r = 0.70) with lipid oxidation, which was increased in the obese children (58 +/- 4 vs. 23 +/- 5 mg/min, P < 0.02). Our data suggest that increased gluconeogenesis from lactate is associated with increased lipid oxidation and could contribute to the progressive ...Continue Reading

References

Jan 1, 1992·The Journal of Clinical Investigation·N NurjhanJ Gerich
Apr 1, 1990·Diabetologia·P A JanssonP Lönnroth
Aug 1, 1970·Canadian Journal of Physiology and Pharmacology·F Depocas, A S DeFreitas

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Citations

Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·S Renee CommerfordMichael J Pagliassotti

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