Alterations of platelet membrane microviscosity in essential hypertension

Clinical Science
K H Le Quan SangM A Devynck


1. The metabolism of blood platelets, taken as an accessible model of excitable cells, has been reported to be altered in hypertension. Most of the identified alterations concern the functions of various plasma membrane constituents. 2. A possible modification of membrane microviscosity was investigated by 1,6-diphenyl-1,3,5-hexatriene and 1-[4-(trimethylamino)phenyl]-6-phenyl-1,3,5-hexatriene fluorescence depolarization. In order to determine whether or not the membrane structures probed by these indicators were related to platelet physiological functions, the cytosolic free Ca2+ concentration was determined in parallel. 3. At physiological temperature, the fluorescence anisotropy of 1-[4-(trimethylamino)phenyl]-6-phenyl-1,3,5-hexatriene was decreased in untreated hypertensive patients (0.276 +/- 0.002 versus 0.288 +/- 0.002, n = 23 and 22, P less than 0.001), indicating a lowered microviscosity at the lipid-water interface of cell membrane. It correlated inversely with blood pressure (P less than 0.001) and cytosolic free Ca2+ concentration (P less than 0.030). On the contrary, 1,6-diphenyl-1,3,5-hexatriene fluorescence anisotropy was observed to vary with sex but not with blood pressure. 4. These results suggest that structu...Continue Reading


May 4, 2010·Cardiovascular Therapeutics·Stephanie W Watts, Robert Patrick Davis
Nov 1, 1993·British Journal of Clinical Pharmacology·K H Le Sang QuanM A Devynck
Aug 4, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T R OliveiraT B Paiva
Jun 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·K H Le Quan SangM A Devynck
Mar 13, 2012·Pharmacological Reviews·Stephanie W WattsSusan M Barman
Aug 1, 2019·American Journal of Physiology. Renal Physiology·Robert L RepettiRajeev Rohatgi
Apr 16, 2005·Clinical Science·Stephanie W Watts
Jan 1, 1991·Life Sciences·K H Le Quan SangM A Devynck
Apr 15, 1993·European Journal of Pharmacology·M A DevynckM Mazeaud

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