Alterations of protein expression in serum of infants with intrauterine growth restriction and different gestational ages

Journal of Proteomics
María D Ruis-GonzálezJuan López-Barea

Abstract

Intrauterine growth restriction (IUGR) is associated with increased morbidity and metabolic anomalies in adults. The serum proteome of venous blood was compared in 43 IUGR and 45 adequate gestational age (AGA) infants, separated into three gestational age groups, "Very Preterm" 29-32weeks, "Moderate Preterm" 33-36w, and, "Term" ≥37weeks, in samples drawn three times from birth to 1month of life. After depleting the abundant serum proteins (ProteoMiner(TM)), expression changes were studied by 2-DE, image analysis (Proteomweaver 4.0(TM)), and identification by MALDI-TOF/TOF. Significant expression differences were found in thirty-four proteins, and thirty-three were identified. Lysophospholipid acyltransferase 7 (MBOAT7), was detected exclusively in IUGR of all gestational ages and sampling times; seven other proteins were found only in AGA. Another twenty-five proteins had intensity changes ≥2.5 folds in IUGR: twenty were upregulated and five downregulated. Western blots confirmed the identification of several proteins: MBOAT7 increased 20.5-fold in IUGR, while AGA had 11.2-fold higher levels of SUMO3 and sumoylated proteins and 13.7-fold higher levels of APOL1. Upregulation of MBOAT7 in IUGR neonates could be an adaptive respon...Continue Reading

References

Jan 1, 1997·Hormone Research·P D Gluckman, J E Harding
Feb 29, 2000·The Journal of Biological Chemistry·H Saitoh, J Hinchey
Feb 24, 2001·Zeitschrift für Geburtshilfe und Neonatologie·A WasilukJ Prokopowicz
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·G EngströmF Lindgärde
Jan 24, 2003·International Journal of Epidemiology·D J P BarkerC Osmond
May 16, 2003·American Journal of Obstetrics and Gynecology·Lori E SilverLony C Castro
Apr 30, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Susan W AucottFrances J Northington
Jun 11, 2004·Annual Review of Nutrition·Elizabeth C Theil
Mar 23, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Juan Rodríguez-SorianoAlfredo Vallo
May 25, 2006·Clinical Obstetrics and Gynecology·Eugenia K Pallotto, Howard W Kilbride
Jun 23, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·H A de Boo, J E Harding
May 17, 2008·Seminars in Perinatology·Nancy Hendrix, Vincenzo Berghella
May 17, 2008·Seminars in Perinatology·Michael G Ross, Marie H Beall
May 17, 2008·Seminars in Perinatology·Adam Rosenberg
Sep 6, 2008·The Journal of Biological Chemistry·Miguel A GijónDennis R Voelker
Dec 27, 2008·The Science of the Total Environment·Amalia Vioque-FernándezJuan López-Barea
Jan 9, 2009·Apoptosis : an International Journal on Programmed Cell Death·Simona SeriniGabriella Calviello
May 20, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Anastasia A Varvarigou
Oct 14, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Angelica DessìVassilios Fanos
Apr 17, 2012·Journal of Perinatal Medicine·Ulrich PecksWerner Rath
Sep 11, 2012·The Journal of Nutritional Biochemistry·Chuang LiuJunjun Wang
Sep 13, 2012·Expert Review of Proteomics·Santo Davide Ferrara, Guido Viel
Oct 3, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Angelica DessìVassilios Fanos
Oct 23, 2012·Analytical Biochemistry·Anne GürtlerAnton Posch
Nov 12, 2013·Pediatrics and Neonatology·Lin-Shien Fu, Ming-Chin Tsai
Jun 7, 2014·Frontiers in Pharmacology·Debargha BasuliSuzy V Torti

❮ Previous
Next ❯

Citations

Apr 14, 2016·Journal of Proteomics·Elisabetta GianazzaIvano Eberini
Feb 15, 2017·Proteomics. Clinical Applications·Somchai ChutipongtanateJisnuson Svasti
Jan 22, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khaled ThabetMohammed Eslam
Mar 31, 2016·Journal of the American Society of Nephrology : JASN·Leslie A BruggemanJohn F O'Toole
Apr 4, 2019·Journal of Cellular and Molecular Medicine·Mariona Guitart-MampelGlòria Garrabou
Aug 9, 2016·Expert Review of Proteomics·Gavino FaaMassimo Castagnola
May 22, 2020·BMC Medical Genetics·Anna K MillerLeslie A Bruggeman
Apr 16, 2021·Clinical Proteomics·Natasha LetunicaVera Ignjatovic
Feb 8, 2018·Journal of Proteome Research·Cristina Pérez-PatiñoJordi Roca

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

© 2022 Meta ULC. All rights reserved