Alterations of regional cerebral blood flow and oxygen saturation in a rat sinus-vein thrombosis model

Stroke; a Journal of Cerebral Circulation
H NakaseO Kempski

Abstract

The pathophysiology of sinus-vein thrombosis (SVT) in patients and experimental animals is still poorly understood. This study was designed to examine and further elucidate the pathophysiological sequence of events, especially the relationship between local and regional blood flow and hemoglobin oxygen saturation (HbSO2) detected at identical locations. The use of both parameters as outcome indicators should be compared. SVT was induced by ligation of the superior sagittal sinus (SSS) and slow injection of kaolin-cephalin suspension into the SSS in rats. Regional cerebral blood flow (rCBF) was assessed by laser-Doppler flowmetry together with regional HbSO2, which was measured by a microspectrophotometric technique at 48 identical locations for 90 minutes after SVT using a scanning technique. Fluorescence angiography was performed before and 30 and 90 minutes after SVT induction. After 48 hours the animals were killed for histology. The fluorescence angiographic findings could divide animals into three groups: (1) group A, with a solitary SSS thrombus (n=8); (2) group B, with a thrombosis of SSS and cortical veins (n=10); (3) group C, animals that had undergone sham operation (n=5). Decreases of rCBF and HbSO2 and brain damage ...Continue Reading

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Citations

Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J RötherM E Moseley
Jan 24, 2006·Anesthesia and Analgesia·Cécile JulienJean-François Payen
Mar 21, 2002·Neurologia Medico-chirurgica·Hiroyuki NakaseToshisuke Sakaki
Aug 10, 2000·Journal of Neurosurgery·H OtsukaT Sakaki
Jul 17, 2001·Journal of Neurosurgery·D G Piepgras
Aug 8, 2013·World Neurosurgery·Jason P RahalCarl B Heilman
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroyuki NakaseToshisuke Sakaki
Nov 1, 2013·European Journal of Radiology·Rakesh Kumar GuptaDheeraj Khurana
Mar 7, 2021·Translational Stroke Research·Marie-Charlotte BourrienneMikaël Mazighi

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